| 摘要: |
| 目的 探究重复经颅直流电刺激后健康大学生前额叶脑区功能连接的变化。方法 选取某大学在读本科生39名，利用随机数表法将被试分为刺激组（n＝21）和对照组（n＝18），使用强度为1.5 mA的经颅直流电刺激对两组被试实施为期4周、共12次的干预（对照组为假刺激），每次干预持续20 min，通过功能性近红外光谱技术在试验前（基线）、试验中（第14天）、试验后（第28天） 3个时间点对被试的前额叶静息态功能连接进行评估。结果 近红外光谱数据显示，P值校正前刺激组发生功能连接变化的通道占比（29.71%）远高于对照组（7.03%）；采用Bonferroni法对P值进行校正后显示，试验后刺激组两侧额叶及额叶间的功能连接较实验前减弱（P’＜0.05），而对照组无明显变化。结论 重复经颅直流电刺激能够降低功能连接，提升前额叶皮质的连通效率。 |
| 关键词: 经颅直流电刺激 功能近红外光谱成像技术 前额叶皮质 功能连接 |
| DOI：10.16781/j.CN31-2187/R.20210325 |
| 投稿时间：2021-03-29修订日期：2021-11-04 |
| 基金项目:军队"十三五"重大项目(AWS17J012). |
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| Effects of repeated transcranial direct current stimulation on functional connectivity of prefrontal cortex in healthy undergraduates |
| LU Hong-liang,WANG Xin-lu,WANG Ying-shuang,SUI Jia-ru,ZHU Xia* |
(Department of Military Psychology, Faculty of Military Medical Psychology, Air Force Medical University, Xi'an 710032, Shaanxi, China
*Corresponding author) |
| Abstract: |
| Objective To investigate the changes of functional connectivity of prefrontal cortex in healthy undergraduates after repeated transcranial direct current stimulation (tDCS).Methods Thirty-nine undergraduates were selected and divided into stimulation group (n＝21) and control group (n＝18) by random number table. tDCS with intensity of 1.5 mA was used to implement 12 interventions for 4 weeks in the stimulation group, and each intervention lasted for 20 min; and the control group was stimulated in the same way by sham tDCS. Functional near infrared spectroscopy (fNIRS) was used to measure the resting prefrontal functional connectivity of pre-test (baseline), in-test (the 14th day) and post-test (the 28th day).Results fNIRS data indicated that the proportion of channels with functional connectivity changes (before P value correction) was much higher in the stimulation group (29.71%) than in the control group (7.03%). The functional connectivity of the bilateral prefrontal lobe and between cerebral hemispheres in the stimulation group was decreased after the experiment compared with before the experiment (P’＜0.05 after Bonferroni correction), but there was no significant change in the control group.Conclusion Repeated tDCS can improve the connectivity efficiency of prefrontal cortex by reducing the strength of functional connectivity. |
| Key words: transcranial direct current stimulation functional near infrared spectroscopy prefrontal cortex functional connectivity |
