| 摘要: |
| G蛋白偶联受体（GPCR）是细胞表面最大的受体家族，广泛分布于人体的中枢神经系统、免疫系统、心血管系统、视网膜等器官和组织，参与机体发育和正常功能的行使。肝脏是人体的重要器官，具有代谢、解毒、分泌和排泄胆汁等功能，肝脏中存在的GPCR参与了多项病理生理过程。本文就GPCR参与急慢性肝损伤的研究进展进行综述。 |
| 关键词: G蛋白偶联受体 肝损伤 纤维化 信号转导 激活方式 |
| DOI：10.16781/j.CN31-2187/R.20211051 |
| 投稿时间：2021-10-20修订日期：2021-12-06 |
| 基金项目:国家自然科学基金(81871579) |
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| Role of G protein-coupled receptor in liver injury: research progress |
| WANG Ying,XIANG Qian,WANG Ting,BIAN Jin-jun* |
(Faculty of Anesthesiology, The First Affiliated Hospital of Naval Medical University (Second Military Medical University), Shanghai 200433, China
*Corresponding author) |
| Abstract: |
| G protein-coupled receptor (GPCR) is the largest receptor family on cell surface, it is widely distributed in organs and tissues such as the central nervous system, immune system, cardiovascular system, and retina, and participates in body development and normal function. Liver is an important organ of human body and has many functions such as metabolism, detoxification, and secretion and excretion of bile. GPCRs in the liver are involved in many pathophysiological processes. This article reviews the research progress of GPCRs involved in acute and chronic liver injury. |
| Key words: G protein-coupled receptor liver injury fibrosis signal transduction activation mode |
