| 摘要: |
| 布比卡因脂质体exparel是目前唯一上市的局部麻醉药缓释制剂，被批准用于成人单次局部浸润麻醉及肌间沟臂丛神经阻滞。随着区域阻滞技术的发展，exparel的超说明书应用逐渐增加。本文综述了近年来exparel在躯干神经阻滞、外周神经阻滞及椎管内麻醉中的应用，评价其安全性和有效性，并关注特殊人群应用的相关研究。 |
| 关键词: exparel 布比卡因脂质体 神经阻滞 区域麻醉 手术后镇痛 |
| DOI：10.16781/j.CN31-2187/R.20211178 |
| 投稿时间：2021-11-20修订日期：2022-03-29 |
| 基金项目:海军军医大学(第二军医大学)第二附属医院创新型临床研究项目(2020YLCYJ-Y19),海军军医大学(第二军医大学)第二附属医院人才建设三年行动计划——"金字塔人才工程"军事医学人才项目(0903). |
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| Application of exparel (liposomal bupivacaine): research progress |
| DENG Mengqiu,JIANG Xin,YUAN Hongbin* |
(Department of Anesthesiology, The Second Affiliated Hospital of Naval Medical University(Second Military Medical University), Shanghai 200003, China
*Corresponding author) |
| Abstract: |
| Liposomal bupivacaine exparel is currently the only local anesthetic sustained-release preparation on the market. It has been approved for single-dose infiltration and interscalene brachial plexus block in adults. With the development of regional anesthesia, off-label use of exparel is gradually increasing. This article reviews the application of exparel in trunk nerve block, peripheral nerve block and intraspinal anesthesia in recent years, evaluates its safety and effectiveness, and pays attention to researches about the application of exparel in special population. |
| Key words: exparel liposomal bupivacaine nerve block regional anesthesia postoperative analgesia |
