| 摘要: |
| 氢气是一种无色无味、具有生物活性的还原性小分子气体，具有抗炎、抗氧化、抗凋亡等生物学功能，可用于多种疾病的辅助治疗。人们使用氢的方式已不局限于氢气吸入，还出现了氢水饮用、含氢溶液注射、含氢透析液透析等新方法，氢的生物学作用得到广泛关注。本文围绕氢气在慢性阻塞性肺疾病、哮喘、肺癌、新型冠状病毒感染、急性肺损伤、肺纤维化等呼吸系统疾病中的作用及研究进展进行讨论。 |
| 关键词: 氢气 呼吸系统疾病 慢性阻塞性肺疾病 哮喘 肺癌 新型冠状病毒感染 急性肺损伤 肺纤维化 |
| DOI：10.16781/j.CN31-2187/R.20211271 |
| 投稿时间：2021-12-16修订日期：2022-07-01 |
| 基金项目:国家自然科学基金（82170033），上海市自然科学基金（21ZR1479200），上海市“社区医学与健康管理科研课题研究”专项基金（2023SQ01），上海市虹口区卫生健康委员会医学科研课题（虹卫2302-43），浙江省基础公益计划项目（LQ22H010001）. |
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| Role of hydrogen in respiratory diseases and research progress |
| LI Li1,ZHU Xingxing2,ZHANG Yi3,SHANG Yan1,3* |
(1. Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Naval Medical University (Second Military Medical University), Shanghai 200433, China;
2. Department of Respiratory and Critical Care Medicine, People's Hospital of Haining, Haining 314400, Zhejiang, China;
3. Department of General Practice, The First Affiliated Hospital of Naval Medical University (Second Military Medical University), Shanghai 200433, China
*Corresponding author) |
| Abstract: |
| Hydrogen is a colorless, odorless, and bioactive reducing small molecule gas with anti-inflammatory, antioxidant, anti-apoptosis, and other biological functions, and it can be used in the adjuvant treatment of a variety of diseases. The application of hydrogen is not only for inhalation, but also for hydrogen water drinking, hydrogen solution injection, hydrogen dialysate dialysis, etc., and its biological role has been widely studied. This article reviews the role of hydrogen in chronic obstructive pulmonary disease, asthma, lung cancer, coronavirus disease 2019, acute lung injury, pulmonary fibrosis, and other respiratory diseases, and discusses the recent research progress. |
| Key words: hydrogen respiratory diseases chronic obstructive pulmonary diseases asthma lung cancer coronavirus disease 2019 acute lung injury pulmonary fibrosis |
