| 摘要: |
| 目的 探讨大覆盖面积（腋窝以下全覆盖）充液式抗荷措施对高过载暴露下小型猪的生理防护效果，验证该措施的有效性，为大覆盖面积充液式抗荷服的研究提供基础实验数据。方法 将小型猪随机分为两组：对照组（无抗荷措施，n＝10）和防护组（采用大覆盖面积充液式抗荷措施，n＝9）。利用载人离心机模拟＋Gz暴露（基线1.4 G，增长率1 G/s，峰值8 G，峰值持续时间60 s），观察高过载暴露下小型猪的眼水平动脉血压（EABP）和＋Gz耐力的变化。结果 防护组小型猪的＋Gz耐力高于对照组，差异有统计学意义［28.22（19.99，251.22）G·s vs 7.58（3.65，19.57）G·s，P<0.01］。防护组小型猪＋Gz峰值暴露期间EABP与暴露前相比下降幅度小于对照组，差异有统计学意义［（109.03±3.45）% vs （176.92±11.84）%，P<0.01］；对照组小型猪EABP平均脉压差低于＋Gz暴露前［（8.06±2.79）mmHg vs（36.96±9.80）mmHg，P<0.01；1 mmHg＝0.133 kPa］，防护组小型猪EABP平均脉压差与＋Gz暴露前相比差异无统计学意义［（48.66±8.74）mmHg vs （45.75±8.82）mmHg，P>0.05］。结论 大覆盖面积充液式抗荷措施可明显减轻＋Gz引起的EABP降低，维持脉压差平稳，提高小型猪的＋Gz耐力。 |
| 关键词: 加速度耐力 大覆盖面积 充液式抗荷 加速度防护 离心机 血压 |
| DOI：10.16781/j.CN31-2187/R.20220075 |
| 投稿时间：2022-01-18修订日期：2022-04-15 |
| 基金项目:海军军医大学（第二军医大学）舰载机飞行人才航空医学保障专项课题（2020-JY01），载人航天领域第四批预先研究项目（020101）. |
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| Physiological protective effect of extended-coverage liquid-filled anti-G measures on miniature swine during high +Gz exposure |
| CHANG Wei△,PENG Zhi-yong△,LIU Shu-lin,LI Chuan-tao,YAO Yong-jie* |
(Department of Aviation Medicine, Naval Medical Center, Naval Medical University(Second Military Medical University), Shanghai 200433, China
△Co-first authors.
* Corresponding author) |
| Abstract: |
| Objective To explore the physiological protective effect of extended-coverage (full coverage below the armpit) liquid-filled anti-G measures on miniature swine during high +Gz exposure, and validate the effectiveness of the measures, so as to provide basic experimental data for the research on extended-coverage liquid-filled anti-G suit. Methods Miniature swine were randomly divided into 2 groups:control group (without any anti-G measures, n=10) and protection group (with extended-coverage liquid-filled anti-G measures, n=9). A human centrifuge was used to simulate +Gz exposure (baseline 1.4 G, onset rate 1 G/s, peak 8 G, duration 60 s). The changes in eye-level arterial blood pressure (EABP) and +Gz tolerance of miniature swine during high +Gz exposure were observed. Results The +Gz tolerance of miniature swine in the protection group was significantly higher than that in the control group (28.22[19.99, 251.22] G·s vs 7.58[3.65, 19.57] G·s, P<0.01). The decrease of EABP of miniature swine during peak +Gz exposure in the protection group was significantly lower than that in the control group ([109.03±3.45]% vs[176.92±11.84]%, P<0.01). The mean pulse-pressure difference of EABP of miniature swine in the control group during peak +Gz exposure was lower than that before +Gz exposure ([8.06±2.79] mmHg vs[36.96±9.80] mmHg, P<0.01; 1 mmHg=0.133 kPa). There was no significant difference between the mean pulse-pressure difference of EABP of miniature swine in the protection group during peak +Gz exposure and that before +Gz exposure ([48.66±8.74] mmHg vs[45.75±8.82] mmHg, P>0.05). Conclusion The use of extended-coverage liquid-filled anti-G measures can significantly mitigate the reduction of EABP induced by +Gz, maintain smooth pulse-pressure difference, and improve +Gz tolerance of miniature swine. |
| Key words: acceleration tolerance extended-coverage liquid-filled anti-G acceleration protection centrifuge blood pressure |
