| 摘要: |
| 血管性认知障碍（VCI）是仅次于阿尔茨海默病的第二大常见认知障碍性疾病，目前尚无有效的干预手段。铁是人体必需的一种金属元素，不仅参与ATP和DNA合成，还与髓鞘合成、神经递质循环密切相关，当铁稳态被破坏时出现中枢神经系统铁沉积。研究表明中枢神经系统铁沉积与认知障碍性疾病有关，如阿尔茨海默病和VCI，但目前对这种联系的具体机制所知甚少。本文总结了中枢神经系统铁沉积的形成过程和分类，概述了中枢神经系统铁沉积与不同类型VCI的相关性，初步探讨了中枢神经系统铁沉积引发VCI的可能机制，试图寻找中枢神经系统铁沉积与VCI的基础及临床联系。 |
| 关键词: 铁沉积 铁代谢 血管性认知障碍 认知障碍 |
| DOI：10.16781/j.CN31-2187/R.20220102 |
| 投稿时间：2022-01-27修订日期：2022-03-09 |
| 基金项目:国家自然科学基金(81871040). |
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| Iron deposition in central nervous system and vascular cognitive impairment:research progress |
| GU Zheng-sheng,DU Bing-ying,WU Wen,YIN Ge,SUN Rui,BI Xiao-ying* |
(Department of Neurology, The First Affiliated Hospital of Naval Medical University (Second Military Medical University), Shanghai 200433, China
*Corresponding author) |
| Abstract: |
| Vascular cognitive impairment (VCI) is the second most common cognitive impairment disease after Alzheimer disease (AD), and there is no effective intervention method at present. Iron is an essential metal element for human body. It is not only involved in the synthesis of ATP and DNA, but also closely related to myelin synthesis and neurotransmitter cycle. When iron homeostasis is disrupted, iron deposition occurs in the central nervous system. Several studies have shown that iron deposition in central nervous system is associated with cognitive disorders, such as AD and VCI, but the specific mechanism of this association is still poorly understood. This paper summarizes the formation and classification of iron deposition in central nervous system, overviews the correlation between iron deposition in central nervous system and different types of VCI, preliminarily discusses the possible mechanism of iron deposition in central nervous system to induce VCI, and tries to understand the basic and clinical relationship between iron deposition in central nervous system and VCI. |
| Key words: iron deposition iron metabolism vascular cognitive impairment cognitive impairment |
