| 摘要: |
| 目的 探讨极速脉搏波传导速度（UFPWV）技术在评估冠心病心绞痛患者颈动脉粥样硬化中的应用价值。方法 选择2020年6月至2021年6月黑龙江中医药大学附属第一医院收治的冠心病心绞痛患者64例为研究对象，按照心绞痛的类型将患者分为稳定组（稳定型心绞痛，34例）和不稳定组（不稳定型心绞痛，30例）；选取同期30名健康志愿者作为健康对照组。收集研究对象的一般资料，二维灰阶超声记录颈总动脉内中膜厚度（IMT）、左心室射血分数，采用UFPWV技术检测颈总动脉收缩期开始时脉搏波传导速度（PWV-BS）、收缩期结束时脉搏波传导速度（PWV-ES），采用ELISA检测斑块稳定性指标血清基质金属蛋白酶 3（MMP-3）、蛋白酶K的水平。结果 稳定组和不稳定组患者的吸烟史、收缩压及颈总动脉IMT均高于健康对照组（P均＜0.05）；心绞痛患者（稳定组和不稳定组患者）颈总动脉PWV-BS、PWV-ES均高于健康对照组（P均＜0.001）；不稳定组患者颈总动脉PWV-ES及血清MMP-3、蛋白酶K水平均高于稳定组（P均＜0.05）；以PWV-ES 水平中位数为分界值，PWV-ES 高水平者血清MMP-3 和蛋白酶K水平均高于PWV-ES 低水平者（P均＜0.01）。结论 利用UFPWV 技术测得的PWV-ES 能够用于评估冠心病心绞痛患者的颈动脉粥样硬化风险，值得推广应用。 |
| 关键词: 脉搏波传导速度 冠心病 心绞痛 颈动脉粥样硬化 |
| DOI：10.16781/j.CN31-2187/R.20220354 |
| 投稿时间：2022-04-28修订日期：2022-07-07 |
| 基金项目:黑龙江省中医药管理局科研项目（ZHY2020-114）． |
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| Application of ultrafast pulse wave velocity technique in assessing the risk of carotid atherosclerosis in patients with coronary heart disease and angina pectoris |
| ZHANG Xue-song1,YU Hai-rong2,SHI Guang-yu1,ZHAO Fang-yuan1,WANG He1,ZHAO Li-na1* |
(1. Department of Ultrasound, The First Affiliated Hospital, Heilongjiang University of Traditional Chinese Medicine, Harbin 150040, Heilongjiang, China;
2. Department of Ultrasound, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100010, China
*Corresponding author) |
| Abstract: |
| Objective To explore the application value of ultrafast pulse wave velocity (UFPWV) technique in evaluating carotid atherosclerosis in patients with coronary heart disease and angina pectoris. Methods A total of 64 patients with coronary heart disease and angina pectoris who were treated in The First Affiliated Hospital, Heilongjiang University of Traditional Chinese Medicine from Jun. 2020 to Jun. 2021 were selected. According to the type of angina pectoris, they were divided into stable group (stable angina pectoris, n=34) and unstable group (unstable angina pectoris, n=30); 30 healthy volunteers in the same period were selected as healthy control group. The general data of patients were collected. Common carotid intima-media thickness (IMT) and left ventricular ejection fraction were recorded by two-dimensional gray-scale ultrasound; pulse wave velocity in beginning of systole (PWV-BS) and pulse wave velocity in ending of systole (PWV-ES) were detected by UFPWV technique; and the levels of arteriosclerosis index matrix metalloproteinase 3 (MMP-3) and proteinase K were detected by enzyme-linked immunosorbent assay. Results The smoking history, systolic blood pressure and common carotid IMT in the stable and unstable groups were significantly higher than those in the control group (all P<0.05); the common carotid PWV-BS and PWV-ES in patients with angina pectoris (in the stable and unstable groups) were significantly higher than those in the control group (both P<0.001); the common carotid PWV-ES and the levels of serum MMP-3 and proteinase K in the unstable group were significantly higher than those in the stable group (all P<0.05); and with the median value of PWV-ES as the cut-off value, the levels of serum MMP-3 and proteinase K in the high PWV-ES level group were significantly higher than those in the low PWV-ES level group (both P<0.01). Conclusion PWV-ES measured by UFPWV technique can be used to assess the risk of carotid atherosclerosis in patients with coronary heart disease and angina pectoris, which is worthy of popularization and application. |
| Key words: pulse wave velocity coronary heart disease angina pectoris carotid atherosclerosis |
