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| 芒果苷的药效作用研究进展 |
| 范香成1,2,焦广洋3,张凤1,2,韩军4,陈万生1,2,3* |
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(1. 海军军医大学(第二军医大学)第二附属医院药剂科, 上海 200003;
2. 上海市药物(中药)代谢产物研究重点实验室, 上海 200433;
3. 上海中医药大学中药研究所, 上海 201203;
4. 海军军医大学(第二军医大学)第二附属医院消化内科, 上海 200003
*通信作者) |
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| 摘要: |
| 芒果苷是一种天然存在的C-葡萄糖基黄酮，是有效的药用化合物，可以从多种植物中分离提取。研究表明，芒果苷具有治疗糖尿病、抗肿瘤、抗炎、抗氧化、治疗眼部疾病、神经系统保护、肾脏保护、改善心血管疾病等作用。其具有众多的生物活性，对预防和治疗多种疾病有巨大潜力。本文对近年来芒果苷的药效学研究进展及其作用机制进行综述，以期为芒果苷的进一步研究和利用提供科学依据。 |
| 关键词: 芒果苷 黄酮 药效学 糖尿病 肿瘤 作用机制 |
| DOI：10.16781/j.CN31-2187/R.20220402 |
| 投稿时间：2022-05-11修订日期：2022-08-23 |
| 基金项目:国家自然科学基金（81830109），海军军医大学（第二军医大学）第二附属医院人才建设三年行动计划——“金字塔人才工程”（0806，1016），海军军医大学（第二军医大学）第二附属医院创新型临床研究项目（2020YLCYJ-Y25）. |
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| Pharmacodynamics of mangiferin: research progress |
| FAN Xiangcheng1,2,JIAO Guangyang3,ZHANG Feng1,2,HAN Jun4,CHEN Wansheng1,2,3* |
(1. Department of Pharmacy, The Second Affiliated Hospital of Naval Medical University (Second Military Medical University), Shanghai 200003, China;
2. Shanghai Key Laboratory of Drug (Traditional Chinese Medicine) Metabolite Research, Shanghai 200433, China;
3. Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China;
4. Department of Gastroenterology, The Second Affiliated Hospital of Naval Medical University (Second Military Medical University), Shanghai 200003, China
*Corresponding author) |
| Abstract: |
| Mangiferin is a naturally derived C-glucosyl flavone, which can be isolated from many plants as a potent pharmaceutical compound. Previous studies indicated that mangiferin exerts an array of pharmacological activities, including anti-diabetes, anti-tumor, anti-inflammation, anti-oxidation, treatment of eye diseases, nervous system protection, kidney protection, and improvement of cardiovascular diseases. Due to its various biological activities, mangiferin has great potential for prevention and treatment of many diseases. This paper summarizes the research progress and the mechanism of mangiferin pharmacodynamics, so as to provide a scientific basis for the further research and utilization of mangiferin. |
| Key words: mangiferin flavone pharmacodynamics diabetes mellitus tumor mechanism of action |
