| 摘要: |
| 组蛋白修饰作为表观遗传学机制之一,在染色质结构、核小体定位、基因表达调控等方面发挥着至关重要的作用。近年研究发现,乙酰化、甲基化、磷酸化、泛素化等组蛋白修饰方式对破骨细胞及成骨细胞分化过程进行调控并影响骨稳态。本文对组蛋白修饰在破骨细胞和成骨细胞分化及功能调节方面的研究进展进行综述。 |
| 关键词: 组蛋白修饰 骨稳态 破骨细胞 成骨细胞 |
| DOI：10.16781/j.CN31-2187/R.20220446 |
| 投稿时间：2022-05-27修订日期：2022-11-14 |
| 基金项目: |
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| Histone modifications regulate differentiation and function of osteoclasts and osteoblasts |
| HOU Yijin1,2,ZHANG Hao2* |
(1. School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China;
2. Department of Orthopaedics Trauma, The First Affiliated Hospital of Naval Medical University(Second Military Medical University), Shanghai 200433, China
*Corresponding author) |
| Abstract: |
| Histone modifications, as one of the epigenetic mechanisms, play a crucial role in chromatin structure, nucleosome localization, and regulation of gene expression. Recent studies have revealed that histone modifications such as acetylation, methylation, phosphorylation and ubiquitination regulate the differentiation of osteoclasts and osteoblasts and affect bone homeostasis. This article reviews the research progress of histone modifications in regulating the differentiation and function of osteoclasts and osteoblasts. |
| Key words: histone modifications bone homeostasis osteoclasts osteoblasts |
