| 摘要: |
| 减压病是由于环境压力下降速度过快或幅度过大，由溶解于体内的惰性气体在血管或组织中形成气泡而引起的一系列症状和体征，严重时可以威胁生命安全。目前，再加压吸氧治疗是减压病的主要治疗措施，但并不能满足重症减压病的治疗需求，仍需药物辅助治疗。防治减压病的可选药物有限，尚未发现特效药物。多年来，学界不断探索用于治疗减压病的药物，如抗血小板药、抗炎药、抗氧化药、气泡消融药及中药等。其中，应用中药防治减压病可能会是减压病防治领域研究的新方向。本文综述了20世纪80年代至今减压病防治药物的研究进展。 |
| 关键词: 减压病 抗炎药 抗血小板药 抗氧化药 中药 |
| DOI：10.16781/j.CN31-2187/R.20220535 |
| 投稿时间：2022-06-22修订日期：2022-12-22 |
| 基金项目: |
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| Drug prevention and treatment of decompression sickness: research progress |
| LIU Cheng1,LI Zhiyong2,ZHANG Yanjie1,GUO Meili1* |
(1. Department of Pharmacognosy, School of Pharmacy, Naval Medical University (Second Military Medical University), Shanghai 200433, China;
2. Department of Pharmacology, School of Pharmacy, Naval Medical University (Second Military Medical University), Shanghai 200433, China
*Corresponding author) |
| Abstract: |
| Decompression sickness (DCS) is a series of symptoms and signs caused by bubbles in blood vessels or tissue with dissolved inert gas due to the rapid or excessive reduction of environmental pressure, which can threaten life safety in severe case. At present, recompression oxygen inhalation therapy is the main treatment of DCS, but it cannot meet the treatment needs of severe DCS, and drug adjuvant therapy is still needed. However, the optional drugs for the prevention and treatment of DCS are limited, and no specific drugs have been found. Over the years, scholars have been constantly exploring drugs for the DCS therapy, such as antiplatelet drugs, anti-inflammatory drugs, antioxidant drugs, bubble ablation drugs, and traditional Chinese medicine. Among them, traditional Chinese medicine may be a new direction in the field of prevention and treatment of DCS. This paper reviews the research progress of drug treatment of DCS since 1980s. |
| Key words: decompression sickness anti-inflammatory drugs antiplatelet drugs antioxidant drugs traditional Chinese medicine |
