| 摘要: |
| 目的 基于中医传承辅助平台分析《中医方剂大辞典》中含地龙方剂组方规律，为地龙现代临床应用和产品研发提供理论依据。方法 整理《中医方剂大辞典》中含地龙的方剂，录入中医传承辅助平台（V2.5）软件，建立数据库，统计配伍药物频次、性味归经频次、主治病证频次,使用平台软件内置的关联规则、改进的互信息法等数据挖掘方法分析含地龙方剂的核心药物组合。选择频次较高的病证“痹证”和“跌打损伤”进行用药关联规则、核心药物组合和新方组合分析。结果 共筛选出含地龙方剂281首，包含药物287味，常用组合药物29种（频次≥20）,配伍药物药性四气以温、寒频次为多，二者共占总频次的73.5%,五味以辛味频次最高，苦、甘、咸频次各次之，此四者共占总频次的95.9%,归经频次以肝、脾、心、胃、膀胱、肾、肺经居前7位（频次均≥400），共占总频次的91.8%。含地龙方剂主治病证共103种，其中频次≥6的病证有18种，核心药物组合（支持度20%）为制川乌、乳香、没药、当归、麝香。分析“痹证”和“跌打损伤”用药规律，得到治疗“痹证”病证关联药物15组（置信度为1），核心药物组合（支持度31.8%）为制川乌、制草乌、乳香、没药、威灵仙、五灵脂,得到治疗“跌打损伤”病证关联药物20组（置信度为0.9），核心药物组合（支持度31.5%）为制川乌、乳香、没药、自然铜、苏木、当归、血竭。结论 《中医方剂大辞典》中地龙多与活血化瘀类、祛风湿类药物配伍，组方用药法度清晰。利用中医传承辅助平台分析含地龙方剂能科学、直观体现地龙的组方规律,分析主治病证所得的核心用药能反映疾病的基本治法，符合临床应用实际。研究所获得的核心药物组合可为临床应用和新药研发提供参考和借鉴。 |
| 关键词: 中医传承辅助平台 中医方剂大辞典 地龙 组方规律 数据挖掘 |
| DOI：10.16781/j.CN31-2187/R.20220764 |
| 投稿时间：2022-09-30修订日期：2023-04-25 |
| 基金项目:国家自然科学基金（31970316，32170274）. |
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| Analysis of prescription rules of Pheretima in the Dictionary of Traditional Chinese Medicine Prescriptions based on TCM Inheritance Support System |
| LI Lei1,ZHAO Jing2,ZHANG Hanming1,ZHANG Lei1* |
(1. Department of Military Pharmaceutical Botany, School of Pharmacy, Naval Medical University (Second Military Medical University), Shanghai 200433, China;
2. Department of Traditional Chinese Medicine, The Second Affiliated Hospital of Naval Medical University (Second Military Medical University), Shanghai 200003, China
*Corresponding author) |
| Abstract: |
| Objective To analyze the prescription rules of Pheretima in the Dictionary of Traditional Chinese Medicine Prescriptions based on the Traditional Chinese Medicine Inheritance Support System (TCMISS), so as to provide a theoretical basis for the modern clinical application and new drug development of Pheretima. Methods The prescriptions containing Pheretima were collected from the Dictionary of Traditional Chinese Medicine Prescriptions and input into TCMISS (V2.5) to establish a database. The frequencies of compatibility medicinal materials, meridian of drug, and attending diseases were analyzed statistically. The association rules of the software and improved mutual information method were used to analyze the core drug combinations. “Bi syndrome” and “traumatic injury” with higher compatibility frequencies were selected and analyzed in respect of the prescription rules, core drug combinations, and new prescription combinations. Results A total of 281 prescriptions, 287 commonly used drugs, and 29 commonly used drug combinations (frequencies≥20) were screened. The frequencies of 4 natures of compatible drugs were mainly warm and cold (73.5% of the total frequency). The frequency of pungent was the highest in 5 flavors, followed by bitter, sweet, and salty (these 4 accounted for 95.9% of the total frequency). The meridian frequencies of the liver, spleen, heart, stomach, bladder, kidney, and lung ranked the top 7 (frequencies≥400), accounting for 91.8% of the total frequency. A total of 103 kinds of diseases were treated with prescriptions containing Pheretima, involving 18 kinds of attending diseases (frequencies≥6). The core drug combinations (support level 20%) was Aconiti Radix Cocta, Olibanum, Myrrha, Angelicae Sinensis Radix, and Moschus. The prescription rules of “Bi syndrome” and “traumatic injury” were analyzed, 15 groups of drugs were obtained for the treatment of “Bi syndrome” (confidence 1), and the core drug combinations (support level 31.8%) were Aconiti Radix Cocta, Aconiti Kusnezoffii Radix Cocta, Olibanum, Myrrha, Clematidis Radix Et Rhizoma, and Faecas Trogopterori; 20 groups of drugs were obtained for the treatment of “traumatic injury” (confidence 0.9), and the core drug combinations (support level 31.5%) were Aconiti Radix Cocta, Olibanum, Myrrha, Pyritum, Sappan Lignum, Angelicae Sinensis Radix, and Draconis Sanguis. Conclusion Pheretima in the Dictionary of Traditional Chinese Medicine Prescriptions is mostly compatible with drugs of promoting blood circulation and removing blood stasis, and dispelling wind and dampness. The prescription and medication method are clear. It can scientifically and intuitively reflect the prescription rules of Pheretima by analyzing the Pheretima prescriptions with TCMISS. The core drugs obtained by analyzing the attending diseases can reflect the basic treatment of the diseases, and it is in line with the clinical practice. The core drug combinations can also provide references for clinical application and new drug development. |
| Key words: TCM Inheritance Support System Dictionary of Traditional Chinese Medicine Prescriptions Pheretima medication regularity data mining |
