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| 巨噬细胞在间充质干细胞治疗骨关节炎中的作用 |
| 张文博1,陈祖祥2,刘镇3,孙爱军3,单乐天2,赵东宝1* |
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(1. 海军军医大学(第二军医大学)第一附属医院风湿免疫科, 上海 200433;
2. 浙江省骨伤研究所, 杭州 311400;
3. 海军军医大学(第二军医大学)基础医学院人体解剖学教研室, 上海 200433
*通信作者) |
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| 摘要: |
| 间充质干细胞（MSC）治疗骨关节炎是目前研究前沿与热点。研究证明，巨噬细胞在MSC治疗骨关节炎中起重要作用，MSC促进巨噬细胞向选择性活化巨噬细胞（M2表型）极化是其治疗骨关节炎的重要机制，这一机制涉及MSC分泌的一些蛋白和miRNA调控。此外，MSC旁分泌物质（如外泌体）治疗骨关节炎展现出与MSC相似的疗效和机制。本文对巨噬细胞在骨关节炎发生、发展中的作用，MSC对巨噬细胞的影响，以及巨噬细胞在MSC治疗骨关节炎中的作用与机制进行综述，为临床积极开展MSC治疗骨关节炎奠定理论基础。 |
| 关键词: 巨噬细胞 骨关节炎 间充质干细胞 微RNA 外泌体 |
| DOI：10.16781/j.CN31-2187/R.20230550 |
| 投稿时间：2023-10-02修订日期：2023-11-07 |
| 基金项目: |
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| Role of macrophages in mesenchymal stem cell therapy for osteoarthritis |
| ZHANG Wenbo1,CHEN Zuxiang2,LIU Zhen3,SUN Aijun3,SHAN Letian2,ZHAO Dongbao1* |
(1. Department of Rheumatology and Immunology, The First Affiliated Hospital of Naval Medical University (Second Military Medical University), Shanghai 200433, China;
2. Bone Trauma Research Institute of Zhejiang Province, Hangzhou 311400, Zhejiang, China;
3. Department of Anatomy, College of Basic Medical Sciences, Naval Medical University (Second Military Medical University), Shanghai 200433, China
*Corresponding author) |
| Abstract: |
| Mesenchymal stem cell (MSC) treatment of osteoarthritis is currently a frontier and focus of research. Studies have demonstrated that macrophages play a significant role in the treatment of osteoarthritis with MSCs. The polarization of macrophages towards the selectively activated macrophage (M2 phenotype), promoted by MSCs, is a crucial mechanism for the treatment of osteoarthritis. This mechanism involves the regulation of certain proteins and miRNAs secreted by MSCs. In addition, MSC paracrine substances (such as exosomes) show similar efficacy and mechanism to MSCs in the treatment of osteoarthritis. This article provides a comprehensive overview of the role of macrophages in the development and progression of osteoarthritis, the impact of MSCs on macrophages, as well as the role and mechanism of macrophages in the treatment of osteoarthritis with MSCs, so as to lay a theoretical foundation for the clinical applications of MSCs in the treatment of osteoarthritis. |
| Key words: macrophage osteoarthritis mesenchymal stem cell microRNA exosome |
