| 摘要: |
| 创伤后应激障碍（PTSD）是个体在经历创伤性事件后出现，以与事件相关的侵入性思维、回避、消极情绪和认知及警觉性增高为主要表现的心理障碍。睡眠障碍也被认为是 PTSD 的核心特征之一。以往的研究在一定程度上揭示了 PTSD 与睡眠障碍相关，但两者关联的生理机制尚不明确。本文概述了 PTSD 和睡眠障碍的临床及生理特征，在此基础上讨论了 PTSD 和睡眠障碍的双向关系，并进一步探讨了 PTSD 与睡眠障碍关系的相关生理机制和脑机制。未来的研究可以从与 PTSD 和睡眠共同相关的脑区及神经环路入手，探索 PTSD 与睡眠双向关系的神经生理机制，为 PTSD 和睡眠障碍的防治提供更多的信息与方法。 |
| 关键词: 创伤后应激障碍 睡眠障碍 双向关系 机制 |
| DOI：10.16781/j.CN31-2187/R.20230136 |
| 投稿时间：2023-02-24修订日期：2023-03-30 |
| 基金项目:国家自然科学基金面上项目（32071086），三航两海创新团队项目（20200106），海军科技供给项目（2020JY17），未来战争医学防护课题（2019WLMS-15）. |
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| Relationship between post-traumatic stress disorder and sleep |
| ZHAN Jingye1△,JIAO Runda2△,OUYANG Hui1,LIU Weizhi1,WU Lili1* |
(1. Department of Basic Psychology, Lab for Post-Traumatic Stress Disorder, Faculty of Psychology, Naval Medical University (Second Military Medical University), Shanghai 200433, China;
2. Graduate School, PLA General Hospital, Beijing 100853, China
△Co-first authors.
* Corresponding author) |
| Abstract: |
| Post-traumatic stress disorder (PTSD), with the principal manifestations as invasive thinking, avoidance, negative emotions and cognition, and increased alertness, is a psychological disorder occurring after traumatic events. Sleep disorders are also considered as one of the core characteristics of PTSD. Previous studies have partly revealed the relationship between PTSD and sleep disorders, but the physiological mechanism of the relationship is still unclear. This article provides an overview of the clinical and physiological characteristics of PTSD and sleep disorders. Based on this, the bidirectional relationship between PTSD and sleep disorders is discussed, and the relevant physiological and brain mechanisms of the relationship between them are further explored. Future research needs to explore the neurophysiological mechanisms underlying the bidirectional relationship between PTSD and sleep by exploring the brain regions and neural circuits associated with both PTSD and sleep, providing more information and methods for the prevention and treatment of PTSD and sleep disorders. |
| Key words: post-traumatic stress disorder sleep disorder bidirectional relationship mechanism |
