| 摘要: |
| 目的 探讨凝血功能与2型糖尿病患者合并外周动脉斑块的相关性。方法 纳入2022年5－8月在我院内分泌科住院治疗的2型糖尿病患者269例，分别根据有无颈动脉斑块和有无下肢动脉斑块将患者分为颈动脉斑块组（131例）和无颈动脉斑块组（138例）、下肢动脉斑块组（134例）和无下肢动脉斑块组（135例）。比较各组患者的一般临床资料及凝血功能指标的差异，采用logistic回归分析评估2型糖尿病合并外周动脉斑块的独立影响因素。结果 颈动脉斑块组患者的纤维蛋白原水平高于无颈动脉斑块组[3.15（2.79，3.79）g/L vs 2.99（2.66，3.42）g/L，P＝0.005]。logistic回归分析显示，纤维蛋白原为2型糖尿病合并颈动脉斑块的独立危险因素（OR＝1.338，95% CI 1.061～2.078，P＜0.05）。下肢动脉斑块组和无下肢动脉斑块组凝血功能指标差异无统计学意义（均P＞0.05）。结论 2型糖尿病合并不同部位外周动脉斑块与凝血功能的相关性不同。合并颈动脉斑块的患者纤维蛋白原水平较无颈动脉斑块的患者升高，且在控制其他混杂因素后纤维蛋白原是颈动脉斑块发生的独立危险因素；而合并下肢动脉斑块与凝血功能指标无关。 |
| 关键词: 2型糖尿病 颈动脉斑块 下肢动脉斑块 纤维蛋白原 |
| DOI：10.16781/j.CN31-2187/R.20240190 |
| 投稿时间：2024-03-27修订日期：2024-08-20 |
| 基金项目: |
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| Correlation between peripheral arterial plaques and coagulation function in patients with type 2 diabetes mellitus |
| CHEN Ben,LU Jin* |
(Department of Endocrinology, The First Affiliated Hospital of Naval Medical University (Second Military Medical University), Shanghai 200433, China
* Corresponding author) |
| Abstract: |
| Objective To investigate the correlation between coagulation function and peripheral arterial plaques in patients with type 2 diabetes mellitus. Methods A total of 269 patients with type 2 diabetes mellitus who were hospitalized in Department of Endocrinology of our hospital from May to Aug. 2022 were enrolled and divided into carotid plaque group (131 cases) and non-carotid plaque group (138 cases), or lower extremity arterial plaque group (134 cases) and non-lower extremity arterial plaque group (135 cases). General data and coagulation function indexes of the patients between groups were compared. Independent influencing factors of type 2 diabetes mellitus complicated with peripheral arterial plaques were evaluated using logistic regression analysis. Results Compared with the non-carotid plaque group, the fibrinogen level was significantly higher in the carotid plaque group (3.15 [2.79, 3.79] g/L vs 2.99 [2.66, 3.42] g/L, P＝0.005). Logistic regression analysis showed that fibrinogen was an independent risk factor of carotid plaque in type 2 diabetes mellitus patients (odds ratio＝ 1.338，95% confidence interval 1.061-2.078, P＜0.05). There was no significant difference in coagulation function indexes between the lower extremity arterial plaque and non-lower extremity arterial plaque groups (all P＞0.05). Conclusion There are different correlations between peripheral arterial plaques in different parts and coagulation function in type 2 diabetes mellitus patients; those with carotid plaque have higher fibrinogen level, and fibrinogen is an independent risk factor for carotid plaque after controlling other confounding factors; however, there is no correlation between lower extremity arterial plaque and coagulation function indexes. |
| Key words: type 2 diabetes mellitus carotid arterial plaque lower extremity arterial plaque fibrinogen |
