| 摘要: |
| 海绵体神经损伤性勃起功能障碍（CNIED）是前列腺癌手术或其他盆腔手术的常见并发症，会对患者预后及生活质量产生负面影响。传统治疗措施能在一定程度上改善病理状态，但疗效有限。干细胞因其再生潜力而备受关注，利用干细胞治疗CNIED的有效性已在多种临床前模型中得到评估；针对脂肪来源干细胞和骨髓间充质干细胞等的Ⅰ/Ⅱ期临床试验正在进行中。然而，干细胞治疗的长期疗效仍是需要考虑的问题。本文综述了干细胞治疗CNIED的研究现状，并总结探讨了干细胞疗法的疗效强化策略。 |
| 关键词: 海绵体神经损伤 勃起功能障碍 干细胞移植 再生疗法 |
| DOI：10.16781/j.CN31-2187/R.20220314 |
| 投稿时间：2022-04-18修订日期：2022-09-02 |
| 基金项目:国家自然科学基金（81872105），国家杰出青年科学基金（82125025），上海市科学技术委员会“科技创新行动计划”国际联合实验室建设项目（18410750200）. |
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| Stem cell therapy for cavernous nerve injury-induced erectile dysfunction: research progress |
| HE Wei1,CAI Minglei1,REN Shancheng2* |
(1. College of Basic Medical Sciences, Naval Medical University (Second Military Medical University), Shanghai 200433, China;
2. Department of Urology, The Second Affiliated Hospital of Naval Medical University (Second Military Medical University), Shanghai 200003, China
*Corresponding author) |
| Abstract: |
| Cavernous nerve injury-induced erectile dysfunction (CNIED) is a common complication of prostate cancer surgery or other pelvic surgery, and it can have a negative impact on the patient’s prognosis and quality of life. Traditional treatments can improve the pathological state to a certain extent, but the efficacy is limited. Stem cells have attracted considerable attention for their regenerative potential, and the effectiveness of stem cell therapy in the treatment of CNIED has been evaluated in various preclinical models. Phase Ⅰ/Ⅱ clinical trials targeting adipose-derived stem cells and bone marrow mesenchymal stem cells are ongoing. However, the long-term efficacy of stem cell therapy is still a question that needs to be considered. This article reviews the current research status of stem cell therapy for CNIED and summarizes and discusses strategies to enhance the efficacy of stem cell therapy. |
| Key words: cavernous nerve injury erectile dysfunction stem cell transplantation regenerative therapy |
