| 摘要: |
| 性别决定区Y相关高迁移率族盒蛋白11（SOX11）最初被认为是支持干细胞神经元分化和神经前体细胞存活的反式作用因子之一。但深入研究发现，SOX11在神经元发育、重塑及再生中都具有转录调节功能，有望成为神经损伤后再生的重要干预靶点。本文综述了SOX11在中枢神经系统中的生理和病理生理功能及其在神经再生中的作用。 |
| 关键词: 性别决定区Y相关高迁移率族盒11 中枢神经系统 分化 发育 再生 |
| DOI：10.16781/j.CN31-2187/R.20210617 |
| 投稿时间：2021-06-20修订日期：2021-09-15 |
| 基金项目:上海市医学创新研究专项（21Y21900400）. |
|
| Role of sex-determining region Y-related high-mobility group box 11 in differentiation, development and regeneration of central nervous system |
| HOU Xiaoxiang,WANG Chunhui,WANG Junyu,ZHANG Danfeng* |
(Department of Neurosurgery, The Second Affiliated Hospital of Naval Medical University (Second Military Medical University), Neurosurgery Institute of PLA, Shanghai Institute of Neurosurgery, Shanghai 200003, China
*Corresponding author) |
| Abstract: |
| Sex-determining region Y-related high-mobility group box 11 (SOX11) was initially considered as one of the trans-acting factors supporting the differentiation of stem cells and the survival of neural precursors. However, in recent studies, it was found that SOX11 played an important role in the transcriptional regulation of the development, shaping and regeneration of neurons, and it was expected to be a target for the regeneration of injured nerves. This article reviews the physiological and pathophysiological functions of SOX11 in the central nervous system and its role in nerve regeneration. |
| Key words: sex-determining region Y-related high-mobility group box 11 central nervous system differentiation development regeneration |
