| 摘要: |
| 创伤性脑损伤（TBI）致死致残率高，多发生于机动车车祸伤或竞技体育运动中。TBI主要包括原发性损伤和继发性损伤。原发性损伤多为外力直接作用所致，继发性损伤包括脑水肿、神经细胞兴奋性毒性损伤、氧化应激损伤、神经炎症等。对TBI继发性损伤的有效干预不仅有助于改善患者预后，还可能降低患者因TBI所致帕金森病等神经退行性疾病的风险。自噬是维持细胞稳态的一种重要调节方式，研究发现神经退行性疾病和TBI中存在自噬功能障碍，推测自噬可能是TBI病理发展过程中的重要环节之一，也是TBI患者晚年罹患阿尔茨海默病等认知障碍性疾病风险增高的可能原因之一。深入研究自噬在TBI病理机制中的作用，有助于为TBI的临床治疗提供新的靶点，同时也为TBI患者认知障碍的防治开发新的思路。 |
| 关键词: 创伤性脑损伤 自噬 自噬通量 线粒体自噬 铁蛋白自噬 |
| DOI：10.16781/j.CN31-2187/R.20240116 |
| 投稿时间：2024-02-19修订日期：2024-09-25 |
| 基金项目: |
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| Autophagy in traumatic brain injury: research progress |
| SHI Hantong,WANG Chengqing,GUO Yangu,YE Yichao,ZHANG Danfeng,HOU Lijun* |
(Department of Neurosurgery, The Second Affiliated Hospital of Naval Medical University (Second Military Medical University), Shanghai 200003, China
*Corresponding author) |
| Abstract: |
| Traumatic brain injury (TBI) is mostly caused by motor vehicle traffic accidents or competitive sports, with high mortality and disability. TBI mainly includes primary injury and secondary injury. Primary injuries were caused directly by external forces. Secondary injuries include brain edema, excitotoxic effect of neuron cells, oxidative stress and neuroinflammation, etc. Effective intervention of secondary injury not only helps to improve the prognosis of patients with TBI, but also reduces the risk of Parkinson’s disease and other neurodegenerative diseases related to TBI. Autophagy is one of approaches to regulate homeostasis in cells, and autophagy dysfunction has been found in several neurodegenerative diseases and TBI. It is speculated that autophagy dysfunction may play an important role in TBI and explain why patients with TBI have higher risk of neurodegenerative disease. Discovering the role of autophagy in the pathological mechanism of TBI may provide new targets for TBI clinical treatment and cognitive impairment prevention in patients with TBI. |
| Key words: traumatic brain injury autophagy autophagic flux mitophagy ferritinophagy |
