| 摘要: |
| 骨骼系统和免疫系统是维持人体生命的两大重要系统。骨质疏松症是骨组织发生的复杂病理变化，而免疫系统紊乱通过各种机制影响成骨细胞和破骨细胞的增殖、分化，是骨质疏松症的病因之一。固有免疫、适应性免疫和免疫细胞因子等通过调控成骨细胞和破骨细胞的信号通路，在骨吸收和骨重建过程中发挥着至关重要的作用。骨质疏松症与免疫系统之间存在密不可分的联系，由此衍生出免疫骨质疏松学。本文对免疫骨质疏松学相关研究进展进行综述，旨在对骨质疏松症的免疫治疗提供参考。 |
| 关键词: 免疫骨质疏松学 骨质疏松 免疫系统 细胞因子 |
| DOI：10.16781/j.CN31-2187/R.20240470 |
| 投稿时间：2024-07-02修订日期：2024-09-25 |
| 基金项目:国家自然科学基金面上项目（82171754，81971484），上海市重点实验室首批开放课题面上培育项目（2025SZ03），海军军医大学校级基础医学研究课题面上孵化项目（2023MS024）. |
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| Immunoporosis: dialogue between immune system and osteoporosis |
| YU Sizhe1△,WANG Guowei1△,ZHAO Dongbao2,WAN Wei2* |
(1. College of Basic Medical Sciences, Naval Medical University (Second Military Medical University), Shanghai 200433, China;
2. Department of Rheumatology and Immunology, The First Affiliated Hospital of Naval Medical University (Second Military Medical University), Shanghai 200433, China
△Co-first authors.
* Corresponding author) |
| Abstract: |
| Skeletal system and immune system are 2 important systems for maintaining human life. Osteoporosis is a complex pathological change of bone tissue. Immune system disorders have become the cause of osteoporosis through affecting the proliferation and differentiation of osteoblasts and osteoclasts. Innate immunity, adaptive immunity, and cytokines play crucial roles in bone resorption and remodeling by regulating the signaling pathways of osteoblasts and osteoclasts. Therefore, immunoporosis has emerged for studying the inseparable relationship between osteoporosis and immune system. This article reviews the research progresses on immunoporosis, aiming to provide references for immunotherapy of osteoporosis. |
| Key words: immunoporosis osteoporosis immune system cytokines |
