| 摘要: |
| 肠道干细胞（ISC）是位于肠道隐窝中的一群具有自我更新和多向分化能力的细胞，在维持肠上皮稳态和损伤修复中发挥重要作用。近年来，随着新型ISC及其相关标志物的不断发现，ISC迁移与再生模型得以进一步完善，极大地推动了相关领域的研究进展。饮食可通过调节肠上皮稳态影响机体代谢，重要机制之一是通过干细胞巢调控ISC的糖脂和能量代谢。本文总结了经典的和新发现的ISC的生物学特征，并分析了常见营养素和不同饮食模式对ISC的影响，为肠道慢性疾病的精准营养预防和治疗提供思路。 |
| 关键词: 小肠 干细胞 膳食 干细胞巢 再生 |
| DOI：10.16781/j.CN31-2187/R.20240836 |
| 投稿时间：2024-12-09修订日期：2025-03-04 |
| 基金项目:国家重点研发计划重点专项（2019YFA0802500）. |
|
| Dietary regulation of intestinal stem cells: research progress |
| YAN Xuede,CAO Dongmei,ZHANG Weiping* |
(Department of Pathophysiology, College of Basic Medical Sciences, Naval Medical University (Second Military Medical University), Shanghai 200433, China
*Corresponding author) |
| Abstract: |
| Intestinal stem cells (ISCs), locating at the base of intestinal crypts and pivotal in orchestrating the homeostasis and damage repair of the intestinal epithelium, are characterized by their self-renewal and multipotential differentiation capabilities. With the continuous discoveries of new ISCs and related markers, the ISC migration and regeneration model has been further improved, greatly promoting the research in related fields. Diet can regulate ISC glycolipid and energy metabolism through influencing the stem cell niche, subsequently modulating overall metabolism. This paper summarizes the biological features of both classical and newly discovered ISCs, and analyzes the effects of common nutrients and different dietary patterns on ISCs, hoping to provide insights for the precise nutrition prevention and treatment of chronic intestinal diseases. |
| Key words: small intestine stem cells diet stem cell niche regeneration |
