| 摘要: |
| 目的：探讨无环鸟苷(ACV)对人白血病细胞的抗增殖和诱导分化作用。方法：将无环鸟苷加入K562细胞培养4 d，测定其活细胞数目、联苯胺染色阳性率，光镜观察形态、组织化学染色。结果：在ACV的作用下，K562细胞的增殖受抑，生长分数降低，并且向具有合成血红蛋白能力的细胞分化。结论：ACV对K562细胞具有抑制增殖和诱导分化作用,该结果可为慢性粒细胞白血病的治疗探索新的途径。 |
| 关键词: 无环鸟苷 慢性粒细胞白血病 |
| DOI： |
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| 基金项目: |
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| The effect of acycloguanosine on inhibiting proliferation and inducing differentiation of K562 cells |
| 孟沛霖,夏放,韩军,袁有忠,居小萍 |
| () |
| Abstract: |
| Objective: To explore whether acycloguanosine (ACV) can inhibit the proliferation and induce the erythrodifferentiation of human myeloid leukemia K562 cells. Methods: K562 cells were cultured with ACV for 4 d to detect cellular changes. Results: When K562 cells grew in a medium containing ACV, the cellular growth and division were gradually suppressed, growth fraction decreased and further differentiation towards the cell producing hemoglobins was found. Conclusion: ACV can inhibit proliferation and induce erythrodifferentiation of K562 cells. |
| Key words: acycloguanosine chronic myeloid leukemia |
