| 摘要: |
| 目的：利用自行建立的条件性位置偏爱模型，探讨N-硝基-L-精氨酸(NO2Arg)对阿片类物质诱导的精神依赖性的影响。方法：通过观察吗啡、二氢埃托啡精神依赖的昆明种小鼠，在皮下注射NO2Arg前后于条件性位置偏爱箱偏爱侧停留的时间，判断小鼠精神依赖情况。结果：4mg/kg NO2Arg使吗啡和二氢埃托啡精神依赖小鼠在偏爱侧停留时间分别由给予NO2Arg前的(6.09±2.02),(7.98±0.72)min增加到给予后的(9.31±1.10)，(9.48±1.21)min(P<0.01)。结论：NO2Arg可逆转吗啡和二氢埃托啡所致的条件性位置偏爱，提示NO在阿片类药物精神依赖性形成中起重要作用。 |
| 关键词: 条件性位置偏爱 精神依赖 N-硝基-L-精氨酸 吗啡 |
| DOI： |
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| 基金项目: |
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| Reverse of NG-nitro-L-arginine on the psychical dependence induced by morphine and dihydroetorphine in mice |
| 陶学斌,谈冶雄,李万亥,黄矛,万兴旺 |
| () |
| Abstract: |
| Objective: To investigate the effect of NG-nitro-L-arginine (NO2Arg) on psychical dependence induced by opiates on the basis of improved conditioned place preference model in mice. Methods:The time in biased side was recorded before and after 4 mg/kg NO2Arg administration in morphine and dihydroetorphine psychically dependent mice. Results: 4 mg/kg NO2Arg could significantly increase the time in biased side in morphine and dihydroetorphine psychically dependent mice. The time in biased side was increased from (6.09±2.02), (7.98±0.72) min to (9.31±1.10), (9.48±1.21) min (P<0.01). Conclusion: NO2Arg could reverse the psychical dependence induced by opiates, suggesting that NO plays an important role in the development of opiate psychical dependence. |
| Key words: conditioned place preference psychical dependence NG-nitro-L-arginine morphine |
