| 摘要: |
| 目的：探讨喉鳞状细胞癌中P16蛋白表达的情况及临床相关性。方法：用免疫组化的方法检测42例喉鳞癌组织中P16蛋白的表达情况。结果：P16蛋白表达的阳性率为47.62％（20/42）。其中声门上型组为40.00％（4/10），声门型组为57.89％（11/19），声门下型组为38.46％（5/13）；细胞分化Ⅰ级组为75.00％(12/16)，Ⅱ？Ⅲ级组为30.77％（8/26）；伴有颈淋巴结转移组为20.00％（3/15），无颈淋巴结转移组为62.96％(17/27)；临床Ⅰ期组为40.00％（8/20），Ⅱ？Ⅳ期组为54.54％（12/22）。结论：提示P16蛋白的表达与癌细胞的分化程度及肿瘤的转移情况有关，与临床分型及分期无关。 |
| 关键词: 喉肿瘤 基因，p16 |
| DOI： |
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| 基金项目: |
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| Examination of P16 protein expression in human laryngeal carcinoma and study of its clinical correlation |
| 范静平,萧璧君,廖建春,吕春雷 |
| () |
| Abstract: |
| Objective：To study the expression of P16 gene and its correlation with clinical cases. Methods：The levels of P16 gene products were examined immunochemically in resected specimens of human laryngeal squamous cell carcinoma. Results： Carcinomas tested： 47.62%（20/42） showed positive staining in the lesions. 40.00%(4/10) in supraglottic cancer group, 57.89%(11/19) in glottic cancer group, 38.46%(5/13) in subglottic cancer group, 75.00%(12/16) in cell differentiation gradeⅠgroup, 30.77%(8/26) in cell differentiation grade Ⅱ？Ⅲ group, 20.00%(3/15) in lymph node metastasis group, 62.96%(17/27) in those without metastasis, 40.00%(8/20) in clinical stageⅠgroup, 54.54%(12/22) in stageⅡ？Ⅳgroup. Conclusion：The expression of P16 protein is related with malignant degree and lymph metastasis in human laryngeal carcinoma. |
| Key words: laryngeal neoplasms gene, P16 |
