| 摘要: |
| 目的：观察烧伤创面抗真菌感染及防治浅部真菌病外用新药复方萘替芬(S1123)的体外抑菌效果和临床疗效。方法：(1) 体外检测萘替芬、酮康唑和S1123的最低抑菌浓度, 比较3种药物的抗真菌效果； (2) 将S1123和对照药品应用于烧伤创面,在治疗前后取创面痂皮进行真菌培养,观察真菌转阴率；(3) 观察S1123冷霜治疗某舰艇部队浅部真菌病患者1 927例的效果。结果：S1123对丝状真菌和酵母菌具有广谱、高效的抑菌作用,对常见的致病真菌――曲霉和念珠菌,其最小抑菌浓度分别为0.156，0.625 μg/ml。临床使用双盲法观察3 d真菌感染转阴率达77.71％,与对照组比较相差非常显著。对浅部真菌病治疗的有效率为95.6％。结论：S1123是一种疗效很好的外用抗真菌新药。 |
| 关键词: 烧伤 真菌病 萘替芬 |
| DOI： |
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| 基金项目: |
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| Preparation and application of compound naftifine vapour and cream |
| 葛绳德,吴建华,温海,李志刚,廖万清 |
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| Abstract: |
| Objective: To evaluate the effects of a new antifungal agent, S1123, on controlling fungal infection on burn wound in vitro and in clinic. Methods: Compare their antifungal effects with 3 different antifungal drugs, naftifine, ketoconole and S1123 by testing their minimal inhibitory concentration (MIC). S1123 and a control drug were used to treat burn wound. The crusts were taken to culture before and after treatment for calculating the negative rate. One thousand nine hundred and twenty-seven patients suffered superficial mycoses on naval vessels were treated with S1123 cream. Results: S1123 was active in vitro against a broad spectrum of fungal and yeast pathogens. MIC of Aspergillus and Candida, 2 main pathogenic genura, was 0.156，0.625 μg/ml. In the clinical administration, invasive fungi of 79.71%burn wound disappeared in 3 d. Compared with the controls, the difference being signifficant statistically (P<0.01). The effective rate on superficial mycoses was 95.6%. Conclusion: S1123 is an new effective external antifungal drug. |
| Key words: burns mycoses naftifine |
