| 摘要: |
| 目的: 研究胶原蛋白的性质及聚甲基丙烯酸羟乙酯[poly(HEMA)]-Ⅲ型胶原烧伤贴膜的制备方法。方法: 从小牛皮中提取Ⅲ型胶原蛋白，与poly(HEMA)、乙二醇混合，用过硫酸铵和偏亚硫酸钠引发交联反应，制成烧伤用贴膜；在膜中加入药物吲哚美辛，并做体外溶出实验。 结果: poly (HEMA)-Ⅲ型胶原贴膜具有良好的弹性、柔软性、吸湿性和粘附性；吲哚美辛的体外累积释放百分量-时间曲线表明，其多孔的海绵状结构是良好的药物释放系统。结论: poly(HEMA)-Ⅲ型胶原的复合物是制备烧伤用创面敷料的良好材料。 |
| 关键词: Ⅲ型胶原 聚甲基丙烯酸羟乙酯 烧伤 创面敷料 |
| DOI： |
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| Study on poly (hydroxyethyl mathacrylate)-collagenⅢ membrane for burn wounds (Ⅰ) |
| 赵长文,魏红,蒋雪涛,蒋长敏 |
| () |
| Abstract: |
| Objective: To study the characteristics of collagen and the preparation of poly-hydroxyethyl methacrylate (HEMA)-collagen membrane. Methods: TypeⅢ collagen extracted from calf fetus skin was mixed thoroughly with HEMA and ethylene glycol. The polymerization was induced by ammonium persulfate and sodium metabisulfite. Results: The poly(HEMA)-collagen membrane was an elastic, flexible, absorbent and adhesive film. The cumulative in vitro release profile of indometacin from the membrane showed that the porous sponges could be used as a good drug release system. Conclusion: The poly(HEMA)-collagen membrane is a good material to be used as a wound dressing for burns. |
| Key words: type Ⅲ collagen poly hydroxyethyl methacrylate burns wound dressing |
