| 摘要: |
| 目的：探讨大肠癌患者癌细胞DNA含量、倍体分布与体内胃泌素（G）、生长抑素(SS）水平变化，以及肿瘤临床病理参数之间的关系。方法：以图像分析法测定40例大肠癌患者癌细胞DNA含量及二倍体偏离指数（2cDI）；放免法测定血清G，血浆、肿瘤、癌近旁粘膜和癌远旁粘膜的SS水平；借助计算机以多因素逐步回归法分析癌细胞DNA含量、2cDI、上述胃肠激素水平与肿瘤临床病理特点之间的关系。结果：肿瘤SS上升伴随着DNA含量和2cDI显著下降（P<0.01）；癌近旁粘膜SS与DNA含量（P<0.05）和2cDI(P<0.01）呈显著正相关；直肠癌细胞DNA含量和2cDI明显增高（P<0.01）。结论：内源性SS参与了对癌细胞DNA合成的调节；提高肿瘤和癌近旁粘膜SS水平将有助于抑制大肠癌细胞内DNA的合成。 |
| 关键词: 大肠肿瘤 脱氧核糖核酸 逐步回归分析 |
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| Analysis of the relation between cancer cell DNA and changes of gastrin and somatostatin in patients with colorectal cancer |
| 施靖华,王元和,陈腾,赵荣华 |
| () |
| Abstract: |
| Objective： To evaluate the relation between DNA contents, 2c deviation indexes(2cDI) of colorectal cancer cells,changes of some gastrointestinal hormones levels,and the cancer clinical pathologic features. Methods: In 40 patients with colorectal cancer, DNA contents, 2cDI of the tumor cells (determined by automatical imaging cytometry), serum gastrin, plasma somatostatin(SS),tumor SS, cancer-adjacent mucosa SS and cancer-distant mucosa SS levels (assayed by RIA), and the cancer clinical pathologic features were analyzed by multiple variable stepwise regression with a computer. Results: The increases of tumor SS closely accompanied by the decrease of the cancer cell DNA contents or 2cDI (P<0.01). Cancer-adjacent mucosa SS had a significant positive correlation to the cancer cell DNA contents or 2cDIs (P<0.05 and P<0.01, respectively). The cancer cell DNA contents and 2cDIs increased significantly in patients with rectal cancer (P<0.01). Conclusion: The endogenous SS may play an important role in the regulation of DNA synthesis in cancer cell, elevating the tumor SS level and keeping the cancer-adjacent mucosa SS at high level, thus inhibiting the DNA sythesis in colorectal cancer cell. |
| Key words: colorectal neoplasms DNA stepwise regression analysis |
