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| 慢性乙型重型肝炎患者外周血各亚群淋巴细胞绝对值的特点 |
| 辛绍杰,邹正升,李保森,赵军,徐东平,陈黎明,邢汉前,金磊,王福生,XINShao-jie,ZOUZheng-sheng,LIBao-sen,ZHAOJun,XUDong-ping,CHENLi-ming,XINGHan-qian,JINLei,WANGFu-sheng |
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| 摘要: |
| 目的:分析慢性乙型重型肝炎(以下简称慢重肝)患者外周血各亚群淋巴细胞绝对值的特点.方法:慢重肝患者61例,乙肝引起的肝硬化26例,慢性乙型肝炎21例,健康志愿者10例.采用流式细胞仪检测各自外周血淋巴细胞CD3+、CD4+、CD8+、NK细胞(CD3-/CD16+/CD56+)、NKT细胞(CD3+/CD16+CD56+)等亚群表达百分比,计算各淋巴细胞亚群绝对值,并进行统计学分析.结果:与乙肝引起的肝硬化、慢性乙型肝炎患者以及健康志愿者相比,慢重肝患者CD3+、CD4+及CD8+T淋巴细胞的绝对值均明显降低(P＜0.01或P＜0.05);与存活者相比,慢重肝死亡患者外周血淋巴细胞、CD3+、CD4+、CD8+、NK细胞、NKT细胞绝对值均有一种降低的趋势但尚未达到统计学意义.结论:慢重肝患者存在一定程度的细胞免疫功能紊乱,可能与其预后存在一定的相关性. |
| 关键词: 肝炎,乙型,慢性、淋巴细胞、预后 |
| DOI：10.3724/SP.J.1008.2006.00413 |
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| 基金项目:国家自然科学基金（30571749）. |
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| Characteristics of peripheral circulating lymphocyte subsets and their clinical implication in severe hepatitis patients with chronic HBV infection |
| 辛绍杰,邹正升,李保森,赵军,徐东平,陈黎明,邢汉前,金磊,王福生,XIN Shao-jie,ZOU Zheng-sheng,LI Bao-sen,ZHAO Jun,XU Dong-ping,CHEN Li-ming,XING Han-qian,JIN Lei,WANG Fu-sheng |
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| Abstract: |
| Objective：To investigate the characteristics of peripheral circulating lymphocyte subsets in severe hepatitis patients with chronic HBV infection（SHPCHI）. Methods： The numbers of circulating lymphocyte subsets, including CD3^＋, CD4^＋ and CD8^＋ , NK cells （CD3^- /CD16^＋/CD56^＋ ）, and NKT cells （CD3^＋/CD16^＋ CD56^＋ ）, were determined in SHPCHI （n = 61 ）, patients with chronic hepatitis B （CHB, n = 21 ）, patients with cirrhosis （ LC, n = 26） and healthy volunteers （ n = 10） by flow cytometry. The absolute values of each lymphocyte subset were calculated and statistically analyzed. Results： The absolute numbers of circulating CD3^＋ , CD4^＋ and CD8^＋ T cells were significantly reduced in SHPCHI group compared with those in the other 3 groups （P〈0.01 or P〈0.05）. There was a decreasing trend in the absolute numbers of peripheral CD3^＋ , CD4^＋ , CD8^＋ and NK cells in non-surviving SHPCHI compared with surviving SHPCHI,but the decrease was not statistically significant. Conclusion： SHPCHI has an disorderd cellular immune function, which might be related to the prognosis of SHPCHI. |
| Key words: hepatitis B, chronic lymphocytes prognosis |
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