| 摘要: |
| 世界上大多数国家都制定了乙型肝炎(乙肝)免疫计划,这为预防性乙肝疫苗的研发提供了导向.从第一代血源性疫苗到重组乙肝疫苗,再到合成肽疫苗和DNA疫苗,乙肝疫苗的研制技术不断进步,其应用范围也已从预防扩展到治疗.本文分析了各国乙肝免疫计划与乙肝疫苗研发的关系,总结了预防性和治疗性乙肝疫苗的研发思路,并提出乙肝疫苗进一步研发的方向. |
| 关键词: 免疫计划、肝炎,乙型、疫苗 |
| DOI：10.3724/SP.J.1008.2006.00774 |
| 投稿时间：2006-05-14修订日期：2006-06-19 |
| 基金项目:中国科学院决策工程(SDP)项目(2005)2-3号. |
|
| Analysis of global hepatitis B vaccine research and development |
| CHEN Da-ming,XIAO Hong |
| (中国科学院研究生院,北京,100039;中国科学院上海生命科学信息中心,上海,200031) |
| Abstract: |
| More than 100 countries have added hepatitis B vaccination to their routine immunization programmes. Hepatitis B vaccines progressed from blood vaccines to recombinant vaccines, then to peptide vaccines and DNA vaccines, to their functions extended from prophylactic to therapeutic. This article analyzes the relationship between hepatitis B vaccine R＆D and the immunization programmes in different countries, to summarizes the R＆D of both prophylactic and therapeutic vaccines,and points out the direction for futare vaccine development. |
| Key words: immunization programme hepatitis B vaccines |
