| 摘要: |
| 糖尿病及其并发症的发生与氧化应激密切相关.血红素氧化酶(heme oxygenase,HO)作为机体重要的防御系统之一可以对抗氧化应激造成的损伤,具有重要的生理作用.HO可以被氧化应激诱导产生,分解血红素生成一氧化碳、胆红素及铁,这些代谢产物具有抗炎、抗氧化损伤和抗凋亡的作用.在高血糖环境中,HO的表达被诱导增高,发挥保护作用,使胰岛细胞、内皮细胞和单核细胞等多种细胞和组织免受氧化损伤.其代谢产物的增加不仅可以维持胰岛细胞的正常功能,延缓糖尿病的进展,而且可以调节血管、神经和肌肉细胞的功能,防止糖尿病并发症的发生. |
| 关键词: 血红素氧化酶、糖尿病、糖尿病并发症 |
| DOI：10.3724/SP.J.1008.2006.00778 |
| 投稿时间：2005-11-05修订日期：2006-04-05 |
| 基金项目: |
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| Protective role of heme oxygnase in diabetes and diabetic complications |
| LIU Min,MU Yi-ming,PAN Chang-yu |
| (解放军总医院内分泌科,北京,100853) |
| Abstract: |
| Oxidative stress is a major contributor to the pathogenesis of diabetes and diabetic complications. Heme oxygenase （HO）, an important part of the human defense system, has been recognized to have significant physiological function against oxidative stress. HO can be stimulated by oxidative stress and decompose into carbon monoxide, biliverdin and iron,all with important anti-inflammatory, anti-oxidative stress and anti-apoptosis effects. Overexpression of HO induced by hyperglycemia can protect cells （including islet cells, endothelial cells and monocytes） and tissues from oxidative damage. Increased HO metabolic products not only maintain the physiological function of islet cells, delay diabetes progression, but also regulate vascular, nerve and muscle function,so as to prevent diabetic complications. |
| Key words: heme oxygenase diabetes mellitus diabetes complications |
