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| 中药鬼针草化学成分的研究 |
| 黄敏珠,陈海生,刘建国,邹晓华,杜景伶,项昭保 |
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| (解放军第117医院药剂科,杭州,310012;第二军医大学药学院天然药物化学教研室,上海,200433;第二军医大学药学院药理学教研室,上海,200433) |
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| 摘要: |
| 目的:研究鬼针草治疗糖尿病的有效化学成分.方法:采用80﹪乙醇渗漉提取,硅胶,反相硅胶,Sephadex- LH20柱层析分离纯化,化学反应和波谱分析鉴定其化学结构.结果:从鬼针草中得到槲皮素(Ⅰ)、金丝桃苷(Ⅱ)、槲皮素-7-O-鼠李糖苷(Ⅲ)、6,7,3',4'-四羟基橙酮(Ⅳ)、4,5-双咖啡sg酰奎宁酸(Ⅴ)、豆甾醇-3-O-葡萄糖苷(Ⅵ)、3,4-二羟基苯甲酸乙酯(Ⅶ) 、奥卡宁(Ⅷ)、木犀草素(Ⅸ).结论:以上化合物除奥卡宁、金丝桃苷外,其余7个化合物均为首次从鬼针草中分离得到. |
| 关键词: 鬼针草、分离和提纯、中药鉴定、糖尿病 |
| DOI：10.3724/SP.J.1008.2006.00888 |
| 投稿时间：2006-03-23修订日期：2006-05-29 |
| 基金项目: |
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| Studies on the chemical constituents of Bidens bipinnata L. |
| HUANG Min-zhu,CHEN Hai-sheng,LIU Jian-guo,ZOU Xiao-hua,DU Jing-ling,XIANG Zhao-bao |
| (解放军第117医院药剂科,杭州,310012;第二军医大学药学院天然药物化学教研室,上海,200433) |
| Abstract: |
| Objective：To investigate the bioactive chemical constituents in Bidens bipinnata L. for treatment of diabetes. Methods： Extraction was done with 80% EtOH; isolation and purification were carried out on silica gel,C18 silica gel column, and Sephadex-LH20 column; and the chemical structures of the products were identified by physicochemical properties and spectral analysis. Results： Nine compounds were obtained from Bidens bipinnata L. and their chemical structures were identified as： quercitin（ Ⅰ ）, hyperoside （ Ⅱ ） ,quercitin-7-O-rhamnopyranoside（ Ⅲ ） ,6,7,3 ＇4 ＇-tetrahydroxy aurone（ Ⅳ ） ,4,5-di-O- caffeoyl quinic acid（ Ⅴ ） ,stigmasterol 3-O-glucopyranoside （ Ⅵ ）, ethyl 3,4-dihydroxybenzoate（ Ⅶ ）, okanin（ Ⅷ ）, and luteolin（ Ⅸ ）. Conelusion： Except for okanin and hyperoside,the rest 7 compounds are isolated from the plant for the first time. |
| Key words: Bidens bipinnata L. isolation and purification TCD identification diabetes mellitus |
