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二杈狗牙花化学成分研究
梁爽,陈海生,杜景伶,王厚鹏,沈阳,黄敏珠
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(第二军医大学药学院天然药物化学教研室,上海,200433)
摘要:
目的:对二杈狗牙花根茎的化学成分进行分离及结构鉴定.方法:利用硅胶柱、凝胶柱及反相硅胶柱等色谱柱技术进行分离,根据理化性质及波谱学方法进行结构鉴定.结果:分离得到7个化合物:α-香树醇(α-amyrin,1),α-香树醇乙酸酯(α-amyrin acetate,2),α-香树醇棕榈酯(α-amyryl palmitate,3),蒲公英甾醇乙酸酯(taraxasterol acetate,4), 毛蕊异黄酮(calycosin,5), 芒柄花素(formononetin,6), farnisin (7,3'-dihydroxy-4'-methoxyflavone,7).结论:化合物1,3~7均为首次从本植物中分离得到, 化合物3~7为首次从该属植物中分得.
关键词:  二杈狗牙花、分离和提纯、中药鉴定
DOI:10.3724/SP.J.1008.2006.00892
投稿时间:2006-01-17修订日期:2006-05-30
基金项目:国家自然科学基金(20272081).
Study on chemical constituents of Tabernaemontana divaricata
LIANG Shuang,CHEN Hai-sheng,DU Jing-ling,WANG Hou-peng,SHEN Yang,HUANG Min-zhu
(第二军医大学药学院天然药物化学教研室,上海,200433)
Abstract:
Objective:To extract and identify the chemical constituents in the roots and stems of Tabernaernontana divaricata. Methods: The solvent extraction approach and silica column chromatography were used for separation of the chemical constituents, and their structures were identified by physicochemical properties and spectra analysis. Results: Seven compounds were isolated and their structures were identified as α-amyrin (1), α-amyrin acetate (2), α-amyryl octadecanoate(3), taraxasterol acetate (4), calycosin (5), formononetin (6) ,and farnisin (7). Conclusion: Compound 1, 3, 4, 5, 6 and 7 are isolated from this plant for the first time, and Compound 3, 4, 5, 6 and 7 are isolated from Tabernaemontan genus for the first time
Key words:  Tabernaemontana divaricata  isolation & purification  TCD identification