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9-芴甲氧羰基氨基酸叔丁基酯的合成
蒋庆锋,周有骏,姚斌,郑灿辉,吕加国,朱驹
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(西藏军区总医院药物研究所,拉萨,850007;第二军医大学药学院药物化学教研室,上海,200433)
摘要:
目的:寻找合成9-芴甲氧羰基氨基酸叔丁基酯的新方法.方法:以9-芴甲氧基碳酰氯与3种不同的氨基酸(甘氨酸、苯丙氨酸和脯氨酸)在碱性条件下分别反应制得相应的9-芴甲氧羰基氨基酸后,再以二碳酸二叔丁基酯作为酯化试剂,以4-二甲氨基吡啶为催化剂,与制得的9-芴甲氧羰基氨基酸反应合成得到相应的9-芴甲氧羰基氨基酸叔丁基酯.结果:采用本法合成得到3个9-芴甲氧羰基氨基酸的叔丁基酯,化合物结构均经1H NMR确证.结论:本法是操作简单、反应条件温和、产率高、适用性广的制备9-芴甲氧羰基氨基酸叔丁基酯的新方法.
关键词:  9-芴甲氧羰基、氨基酸、叔丁基酯、合成
DOI:10.3724/SP.J.1008.2007.00101
投稿时间:2006-07-24修订日期:2006-11-29
基金项目:
Synthesis of 9-fluorenylmethoxycarbonyl amino acid tert-butyl ester
JIANG Qing-feng,ZHOU You-jun,YAO Bin,ZHENG Can-hui,L(U) Jia-guo,ZHU Ju
(西藏军区总医院药物研究所,拉萨,850007;第二军医大学药学院药物化学教研室,上海,200433)
Abstract:
Objective:To search for a new method for synthesis of 9-fluorenylmethoxycarbonyl amino acid tert-butyl ester. Methods: Glycine, L-Proline, and L-Phenylanaline were separately allowed to react with 9-fluorenylmethylchloroformate to obtain the corresponding 9-fluorenylmethoxycarbonyl amino acids. With 4-(dimethylamine) pyridine (DMAP) used as catalyst, the 9-fluorenylmethoxycarbonyl amino acids were allowed to react with Tert-butyl dicarbonate for the corresponding 9-fluorenyl- methoxycarbonyl amino acid tert-butyl esters. Results: Three 9-fluorenylmethoxycarbonyl amino acid tert-butyl esters were successfully synthesized by this method and their structures were confirmed by 1^HNMR. Conclusion: Ours is a simple method with mild condition and high yielding rate for synthesis of 9-fluorenylmethoxycarbonyl amino acid tert-butyl esters.
Key words:  9-Fluorenylmethoxycarbonyl  amino acid  tert-butyl ester  synthesis