摘要: |
过氧化物酶体增殖物激活受体(peroxisome proliferator-activated receptor,PPAR)属于核受体超家族成员,可分为三种亚型(PPARα、PPARβ/δ、PPARγ),PPARγ在脂肪形成、脂质代谢、胰岛素敏感性、炎症反应、动脉粥样硬化、血压调节等方面发挥重要作用,本文将就其与糖尿病肾病的关系作一综述。[著者文摘] |
关键词: 糖尿病肾病 PPARγ 噻唑烷二酮类 |
DOI:10.3724/SP.J.1008.2006.01372 |
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基金项目: |
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Peroxisome proliferator-activated receptor-alpha and diabetic nephropathy |
HUANG Jie-li, YUAN Ai-hong |
(Department of Nephrology, Tongji Hospital, Tongji University, Shanghai 200065, China) |
Abstract: |
Peroxisome proliferator-activated receptor (PPAR), a member of nuclear hormone receptor superfamily, has 3 subtypes, namely, PPARα, PPARβ/δ, and PPARγ; among them PPARγ plays an important role in adipogenesis, lipid metabolism, insulin sensitivity, inflammation, atherosclerosis, and blood pressure controlling. This article reviews the relationship between PPARγ and diabetic nephropathy.[著者文摘] |
Key words: diabetic nephropathies PPAR gamma thiazolidinediones |