| 摘要: |
| 肝缺血-再灌注损伤(IRI)是肝外科手术尤其是肝移植面临的一大问题，由于肝IRI的机制尚未完全阐明，目前临床上在肝IRI的诊断、预防及治疗等方面均无很有效的措施。本文综述了近年来IRI损伤研究中发现的几个较新的分子标志物的研究进展，包括转录因子信号转导和转录激活子(signal transducer and activator of transcription，STAT)、低氧诱导因子1 (hypoxia-inducible factor 1，HIF-1)、过氧化物酶体增殖物激活受体 (peroxisome proliferator 2 activated receptor， PPAR)，胞质内信号转导因子促有丝分裂原活化蛋白激酶(mitogen-activated protein kinase，MAPK)、Toll样膜受体(toll-like receptor 4，TLR4)、凝血酶受体 (protease-activated receptors， PARs)，及作为效应因子的可诱导一氧化氮合酶(inducible nitric oxide synthase ，iNOS)等，它们与细胞的信号转导系统相关。动物实验研究中发现激活或阻断这些分子对IRI有保护作用，其有可能成为临床诊断、预防及治疗IRI的靶标。 |
| 关键词: 肝 缺血-再灌注损伤 分子标志物 |
| DOI：10.3724/SP.J.1008.2008.00699 |
| 投稿时间：2007-01-19 |
| 基金项目: |
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| Markers of hepatic ischemia-reperfusion injury:a recent progress |
| XIA Chun-yan,CONG Wen-ming* |
| (Department of Pathology,Eastern Hepatobiliary Hospital,Second Military Medical University,Shanghai 200438,China) |
| Abstract: |
| Hepatic ischemia-reperfusion injury (IRI) is a critical problem of liver surgery,especially when comes to liver transplantation.Presently,there are no effective measures for diagnosis,prevention and therapy of IRI,as the mechanisms of IRI still remain unclear.This review summarizes several new hepatic ischemia-reperfusion markers related to cell signal transduction pathway,including transcription factor STAT，HIF-1 and PPARs,transmission factor MAPK， membrane receptor TLR4 and PARs,and iNOS.Animal studies have indicated that IRI was ameliorated by activating or blockading these markers, which might serve as targets for diagnosis,prevention and therapy of IRI. |
| Key words: liver ischemia-reperfusion injury markers |
