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天冬总皂苷对麻醉犬脑血流量及脑血管阻力的影响
刘建国,陈海生*,徐从立,沈阳
0
(第二军医大学药学院天然药物化学教研室,上海 200433)
摘要:
目的:研究天冬总皂苷灌胃给药对麻醉犬脑血流量(CBF)及脑血管阻力(CVR)的影响。方法:杂种犬30只,体质量(11±1.5) kg,雌雄兼用,随即分为5组(每组6只):阴性对照组(生理盐水5 ml/kg,灌胃给药)、阳性对照组(尼莫地平注射液 300 μg/kg,iv)、天冬总皂苷按10、30、60 mg/kg分低中高3个剂量组,灌胃给药。犬用戊巴比妥钠30 mg/kg静脉注射麻醉,手术暴露右侧颈总动脉,用MFV-3200型电磁流量计测定CBF和CVR;MPA3000生物电放大器记录血压(SBP、DBP)和心率(HR)等指标。结果:与阴性对照组比较,天冬总皂苷30、60 mg/kg组于给药后5 min即能明显增加CBF并一直持续到120 min (P<0.01),CBF随剂量增加而增加,显示出有较好的量效关系;天冬总皂苷30、60 mg/kg组用药后CVR虽较用药前降低,但大部分时间点未达到统计学显著意义;天冬总皂苷10 mg/kg组CBF、CVR无明显变化。结论:天冬总皂苷灌胃给药有显著增加麻醉犬CBF的作用。
关键词:  天冬总皂苷  麻醉  脑血流  脑血管阻力  血压  心率
DOI:10.3724/SP.J.1008.2008.00431
投稿时间:2007-05-16修订日期:2008-02-29
基金项目:国家自然科学基金(20472113).
Influence of total saponins from Asparagus cochinchinensis on cerebral blood flow and vascular resistance in anesthetized dogs
LIU Jian-guo,CHEN Hai-sheng*,XU Cong-li,SHEN Yang
(Department of Natural Medicinal Chemistry,School of Pharmacy,Second Military Medical University,Shanghai 200433,China)
Abstract:
Objective:To study the effect of total saponins on cerebral blood flow and vascular resistance in anesthetized dogs.Methods: Thirty hybrid dogs in either sex,with a body weight of (11±1.5) kg,were evenly randomized into 5 groups:negative control group(saline 5 ml/kg,ig),positive control (nimodipine 300 μg/kg,iv),and 3 groups treated with total saponins (low-dose group \[10 mg/kg,ig\],middle-dose group\[30 mg/kg,ig\],and high-dose group\[60 mg/kg,ig\]).The dogs were anesthetized with intravenous pentobarbital sodium (30 mg/kg).The right common carotid artery was exposed to measure the cerebral blood flow,cerebral vascular resistance,blood pressure and heart rate using the MFV-3200 electromagnetic flow meter and MPA-3000 bioelectricity signal-amplifier.Results: Compared with negative control, cerebral blood flow was significantly increased in animals treated with asparagus root saponins(30 and 60 mg/kg,ig)during 5 and 120 min after drug administration (P<0.01). No significant effect on cerebral blood flow and vascular resistance was found in animals treated with asparagus root saponins(10 mg/kg). Conclusion: Asparagus root saponins can increase cerebral blood flow in anesthetized dogs. \[KEY WORDS\]total saponins from Asparagus cochinchinensis; anesthesia; cerebral blood flow; vascular resistance; blood pressure; heart rate
Key words:  total saponins from Asparagus cochinchinensis  anesthesia  cerebral blood flow  vascular resistance  blood pressure  heart rate