| 摘要: |
| 目的:研制可显影固体栓塞剂硫酸钡海藻酸钠微球。方法:采用乳化-离子交联法制备微球,正交设计优化工艺,并考察微球的粒径、形态、分布、稳定性、悬浮性、包封率及X线显影性等理化特性。结果:微球平均粒径为(53.08±32.72) μm,分散良好,形态圆整;微球100℃水浴加热2 h、-4℃冰冻24 h、37℃振摇24 h、钴60(10 kGy)照射0.5 h各组的破损率分别为(2.0±1.1)%、(86.0±19.2)%、(39.0±14.7)%和(10.3±3.2)%;0.25%海藻酸钠微球混悬液的沉降体积比为(0.92±0.018);硫酸钡投料量为2.0 g时包封率为(69.2±13.2)%,且显影效果佳。结论:海藻酸钠、壳聚糖可作为硫酸钡微球的包封材料,乳化-离子交联法适用于此微球的制备。 |
| 关键词: 硫酸钡 海藻酸钠 微球体 |
| DOI：10.3724/SP.J.1008.2008.00833 |
| 投稿时间：2007-06-21修订日期：2008-06-11 |
| 基金项目: |
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| Preparation of X-ray developable alginate-barium sulfate microspheres as material for embolic agent |
| GONG Chun-gui1,WANGXin-xia1,TANG Jie3,XU Ai-min2* |
| (1.Department of Pharmacy,Eastern Hepatobiliary Hospital,Second Military Medical University,Shanghai 200438，China;2.Department of Radiologic Intervention,Eastern Hepatobiliary Hospital,Second Military Medical University,Shanghai 200438;3.Grade 2002,School of Pharmacy,Second Military Medical University,Shanghai 200433) |
| Abstract: |
| Objective:To prepare an X-ray developable alginate-barium sulfate microspheres as material for embolic agent.Methods: The emulsification-internal gelation technique was used to prepare alginate microspheres and the orthogonal design was adopted to optimize the technique.The diameter,shape,dispersibility,stability,suspension property,coating ratio and developability under X-ray of the microspheres were examined.Results: The average diameter of the microspheres was (53.08±32.72) μm; they were well distributed and had a round shape.The ratio of the destroyed microspheres was (2.0±1.1)% after heated at 100℃for 2 h,(86.0±19.2)% after frozen at -4℃ for 24 h,(39.0±14.7)% after vibrated at 37℃ for 24 h,and (10.3±3.2)% after irradiated with 60Co(10kGy)for 0.5 h.The ratio of sedimentation volume in 0.25% suspension of sodium alginate microspheres was (0.92±0.018).The coating rate was (69.2±13.2)% when the feeding amount of barium sulfate was 2.0 g,and the result of X-ray development was good.Conclusion: Alginate-chitosan can be used for the preparation of barium sulfate microspheres; and the emulsification-internal gelation technique can prepare the microspheres with good dispersibility and shape. |
| Key words: barium sulfate sodium alginate microspheres |
