| 摘要: |
| 受体酪氨酸激酶是一个具有内在酪氨酸蛋白激酶活性的膜受体超家族，成员众多，信号转导通路复杂多样。受体酪氨酸激酶激活后，既可以通过磷酸化其下游信号分子，影响基因转录和表达的过程，从而在细胞生长、增殖、分化和代谢方面起重要的调节作用;也可以通过活化下游分子对细胞功能进行快速调节包括对离子通道功能的调节。钾离子通道具有稳定细胞膜电位和调节细胞兴奋性的重要作用。本文主要就受体酪氨酸激酶对钾离子通道功能快速调节及目前的研究进展进行综述。 |
| 关键词: 受体酪氨酸激酶 信号转导 钾通道 调节 |
| DOI：10.3724/SP.J.1008.2008.00206 |
| 投稿时间：2007-07-04 |
| 基金项目:国家自然科学基金(30270361)；科技部重大基础研究前期研究专项课题(2003CCA00300)；国家杰出青年基金(30325038). |
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| Modulation of potassium channels by receptor tyrosine kinases:recent progress |
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| Abstract: |
| Receptor tyrosine kinase (RTK),a membrane receptor superfamily with intrinsic protein tyrosine kinase activity,has many members and complicated signal transduction pathways. Activation of RTKs can trigger a series of signal transduction pathways and play essential roles in modulating cell growth,proliferation,differentiation and metabolism through influencing gene transcription and expression. Activation of RTK can also rapidly modulate some cellular functions including the modulation of ion channels. Potassium channels play a critical role in stabilization of membrane potential and regulation of cellular excitability. This review highlights the rapid modulation of potassium channels by RTKs and reviews the recent progress in related research. |
| Key words: receptor tyrosine kinases signal transduction potassium channels modulation |
