| 摘要: |
| 目的：探讨溃疡性结肠炎(ulcerative colitis,UC)病变范围与临床、内镜和病理特点的关系。方法：回顾性分析75例UC的临床、内镜和病理资料，包括远端型结肠炎17例(22.67%)，左半结肠炎27例(36%)，广泛性/全结肠炎31例(41.33%)。结果：不同病变范围UC组间，患者的性别和发病年龄差异无统计学意义，各种主要临床表现和并发症的发生率随病变范围扩大而增加，其中贫血、低蛋白血症和肠外表现的发生率组间差异显著(P<0.05)。UC病变范围与临床严重度(r=0.418,P<0.001)和内镜下活动度(r=0.239，P=0.039)呈正相关。肠上皮不典型增生的发生率在全结肠炎组显著高于远端型结肠炎组和左半结肠炎组(P<0.05)。结论：UC病变范围与其临床、内镜和病理特点有关，与临床严重度和内镜下活动度呈正相关。 |
| 关键词: 溃疡性结肠炎 病变范围 临床特点 内镜检查 临床病理学 |
| DOI：10.3724/SP.J.1008.2008.00276 |
| 投稿时间：2007-07-22修订日期：2008-01-14 |
| 基金项目: |
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| Relationship of involvement area with clinical,endoscopic and pathological characteristics of ulcerative colitis |
| HUA Ting-yan1,HUANG Jie-fei1*,ZHANG Jian-guo2,QIN Zheng-ji3 |
| (1.Department of Endocrinology,Affiliated Hospital of Nantong University,Nantong 226001,China;2.Department of Pathology,Affiliated Hospital of Nantong University,Nantong 226001;3.Department of Medical Stitastics,Department of Public Health,Nantong University,Nantong 226001) |
| Abstract: |
| Objective：To investigate the relationship of involvement area with the clinical,endoscopic and pathological characteristics of ulcerative colitis (UC). Methods: We retrospectively studied the clinical,endoscopic and pathological data of 75 patients with UC,including 17(22.67%) with distal colitis,27(36%) with left-sided colitis and 31(41.33%) with extensive colitis/pancolitis. Results: No differences were found in the gender and age of onset between different groups. The incidences of main clinical manifestations and complications increased with the increase of the UC involvement,with significant difference found in the incidences of anemia,hypoproteinemia and extraintestinal manifestations between different groups (P<0.05). Positive correlation was found between the UC involvement with the UC severity (r=0.418,P<0.001) and disease activity under endoscopy (r=0.239,P=0.039). The incidence of atypical hyperplasia of enteric epithelium in extensive colitis/pancolitis group was significantly higher than those in the other 2 groups (both P<0.05). Conclusion: The UC involvement is related to the clinical,endoscopic and pathological characteristics of UC; the involvement is positively correlated with the clinical severity and disease activity of UC under coloscopy. |
| Key words: ulcerative colitis disease extent clinical feature endoscopy clinical pathology |
