| 摘要: |
| 目的：对对萼猕猴桃的根与茎进行比较研究，为扩大对萼猕猴桃的用药部位提供实验依据。方法：对其根与茎从性状、理化性质、有效成分含量、药理作用方面进行比较研究。结果：两者都呈生物碱、皂苷阳性反应；紫外-可见吸收光谱都存在280 nm吸收峰；水浸出物得率分别为5.35%、5.68%；dihydrodehydrodiconiferyl alcohol含量分别为0.005 01%、0.006 41%；对HL60肿瘤细胞株的IC50分别为62.39 mg和75.51 mg，对K562白血病细胞株的IC50分别为70.47 mg和77.46 mg，对小鼠皮下移植H22肿瘤的抑制率分别为50.09%和44.52%；两者的自由基清除能力和还原作用相近；两者都不具有镇痛作用。结论：两者除性状差异显著外，在理化性质、有效成分含量、药理作用方面，茎与根的总体情况相近，茎代替根入药具有较高的可行性。 |
| 关键词: 对萼猕猴桃 中药性状鉴定 中药理化鉴定 药理作用 |
| DOI：10.3724/SP.J.1008.2008.00298 |
| 投稿时间：2007-07-24修订日期：2008-01-23 |
| 基金项目:国家自然科学基金（30572360）;上海市科委中药现代化专项基金（04DZ19808）. |
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| A comparison between the root and stalk of Actinidia valvata |
| XIN Hai-liang1,2,WU Ying-chun3,XU Yan-feng1,ZHANG Ya-ni1,LING Chang-quan1* |
| (1.Department of Traditional Chinese Medicine,Changhai Hospital, Second Military Medical University,Shanghai 200433,China;2.Department of Medicine and Apparatus,No.546 Hospital of PLA,Urumqi 841700;3.School of Chinese Materia Medica, Jilin Agriculture University, Changchun 130118) |
| Abstract: |
| Objective：To make a comparative study on the root and stalk of Actinidia valvata, so as to lay a ground for expanding medicinal part of Actinidia valvata. Methods: A comparative study was made between the root and stalk of Actinidia valvata on the following aspects: macroscopical properties, physical and chemical properties, contents of active constituents, and pharmacological actions. Results: The root and stalk of Actinidia valvata both showed positive reaction for alkaloids and saponin, and both had 280 nm absorption peak in UV-Vis spectrum. The aqueous extraction yield of the root and stalk were 5.35% and 5.68%, respectively; the contents of dihydrodehydrodiconiferyl alcohol were 0.005 01% and 0.006 41%, respectively. The IC50 of root and stalk extracts against HL60 were 62.39 mg and 75.51 mg, respectively; and against K562 were 70.47 mg and 77.46 mg, respectively. Their extracts had similar scavenging activity for free radicals and reductive effect; neither of them had analgesia actions.Conclusion: The root and stalk of Actinidia valvata have similar physical and chemical properties, contents of active constituents and pharmacological actions, suggesting that it is highly possible to substitute the root of Actinidia valvata with stalk for medicinal usage. |
| Key words: Actinidia valvata TCD characteristic identific TCD physic chem identific pharmacological actions |
