| 摘要: |
| 目的：观察射频消融犬右肺静脉(RPV)脂肪垫对Bezold-Jarisch反射(BJR)的影响。方法：选用10只杂种犬麻醉后经右侧开胸，暴露RPV脂肪垫，测定基础状态下窦性周长(SCL)、动脉收缩压(SAP)、动脉舒张压(DAP)、平均动脉压(MAP)、左心室收缩压(LVSP)、左心室舒张压(LVDP)、左心室平均压(MLVP)；经左心室导管弹丸式推注藜芦定(每kg体质量10 μg)诱发BJR，观察上述指标的变化，计算各指标的变化值（ΔSCL、ΔSAP、ΔDAP、ΔMAP、ΔLVSP、ΔLVDP、ΔMLVP）；射频消融RPV脂肪垫后推注相同剂量藜芦定，再次观察上述指标的变化值。结果：8只犬顺利完成实验，左心室推注藜芦定后均诱发出BJR，表现为SCL延长，动脉压及左室压下降。与消融前推注藜芦定相比，RPV脂肪垫消融后ΔSCL（ms）显著减小(229.2±92.3 vs 39.3±14.1，P<0.01)，ΔDAP、ΔMAP亦显著减小（P<0.05），其余变化值虽有所减少，但无统计学差异。结论：射频消融犬RPV脂肪垫明显消弱了藜芦定诱发BJR时的心率下降，减弱了动脉舒张压及平均压的降低。 |
| 关键词: 导管消融术 心脏脂肪垫 肺静脉 Bezold-Jarisch反射 |
| DOI：10.3724/SP.J.1008.2007.01335 |
| 投稿时间：2007-09-03修订日期：2007-12-05 |
| 基金项目:国家自然科学基金(30570761). |
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| Radiofrequency ablation of cardiac fat pad at right pulmonary vein-atria junction attenuates Bezold-Jarisch reflex in canine |
| ZHAO Wei, LIAO De-ning*, XIA Yang, ZHAO Xue, ZHANG Jia-you, GU Xing-jian |
| (Department of Cardiovasology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China) |
| Abstract: |
| Objective：To observe the influence of radiofrequency catheter ablation of the fat pad at the right pulmonary vein-atria junction (RPV fat pad) on Bezold-Jarisch reflex (BJR) induced by veratridine in canine. Methods: Ten mongrel dogs were anesthetized and their chest were opened through a right thoracotomy to expose the RPV fat pad. Veratridine was injected into the left ventricle at bolus doses of 10 μg/kg through a catheter to induce BJR. The sinus cycle length (SCL), systolic arterial pressure (SAP), diastolic arterial pressure (DAP), mean arterial pressure (MAP), left ventricle systolic pressure (LVSP), left ventricle diastolic pressure (LVDP) and mean left ventricle pressure (MLVP) were measured under the baseline and after ablation of the RPV fat pad; the changes of the above parameters (ΔSCL, ΔSAP, ΔDAP, ΔMAP, ΔLVSP, ΔLVDP, and ΔMLVP) were calculated. Then the same dose of veratridine was injected under the pad after ablation and the changes of the above parameters were observed. Results: BJR was successfully induced in the 8 animals; the animals has prolonged sinus cycle length (SCL) and decreased MAP and MLVP. After ablation, the prolongation of SCL after injection of veratridine was markedly reduced (\[229.2±92.3\] ms vs \[39.3±14.1\] ms，P<0.01). All the pressures were decreased after injection of veratridine, with significant decrease found only for DAP and MAP (both P<0.05). Conclusion: Ablation of the RPV fat pad can effectively attenuate the decrement of heart rate and the decrement of DAP and MAP during the BJR induced by veratridine, which provides a basis for the radiofrequency catheter ablation of vagus ganglions through endocardium. |
| Key words: catheter ablation cardiac fat pad pulmonary veins Bezold-Jarisch reflex |
