摘要: |
目的:回顾性分析原发性肝细胞癌(HCC)临床常用实验室指标,寻找与HCC诊断相关的指标。方法:收集828例病理确诊为HCC患者术前检查中的常用肿瘤标志物、血清学生化指标、乙型肝炎病毒(HBV)标志物、HBV DNA滴度等临床实验室数据,分析其与肿瘤大小和肿瘤病理分级之间的相关性。结果:828例中97.7%的患者有HBV感染,其中70.9%的患者伴有不同程度的肝纤维化。HCC患者中肿瘤大小与白蛋白(ALB)、球蛋白(GLB)、白球比(ALB/GLB)、天冬氨酸转氨酶(AST)、AST/ALT、γ-谷氨酰转移酶(GGT)、碱性磷酸酶(ALP)、α-岩藻糖苷酶(AFU)、甲胎蛋白(AFP)、肿瘤分级多项指标有相关性,肿瘤的病理分级(分化程度)与前白蛋白(PALB)、GGT、肿瘤大小有相关性(P<0.05)。结论:HCC进展与临床实验室多项生化、肿瘤、病毒指标存在相关性,综合应用这些指标对HCC的辅助诊断价值值得进一步研究。 |
关键词: N-糖组 癌,肝细胞 电泳,毛细管 |
DOI:10.3724/SP.J.1008.2007.01280 |
投稿时间:2007-09-21修订日期:2007-10-15 |
基金项目:国家自然科学基金(30571774);上海市科学委员会登山计划(064119522). |
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Expression of N-glycome in sera of patients with hepatocellular carcinoma |
ZHAO Yun-peng1, GAO Chun-fang1*, FANG Meng1, SUN Shu-han2,LIU Yan1,CHEN Dong-mei1,CAI Mei-lin1 |
(1.Department of Laboratory Medicine, Eastern Hepatobiliary Hospital, Shanghai 200438,China;2.Department of Medical Genetics, College of Basic Medicine Sciences, Second Military Medical University, Shanghai 200433) |
Abstract: |
Objective:To retrospectively analyze the routine clinical laboratory parameters for hepatocellular carcinoma, in an attempt to search for parameters for diagnosis of hepatocellular carcinoma(HCC). Methods: The pre-operation clinical laboratory data, such as tumor makers, and serological biochemical indices, hepatitis B virus (HBV) infection markers, and HBV DNA titers, were collected from 828 patients who were pathologically diagnosed as having HCC; then the correlation between these data with tumor size and the pathological grades of HCC was analyzed. Results:It was found that 97.9% of the 828 patients were infected with HBV and 70.9% of them were accompanied by liver fibrosis. We also found that the tumor size was correlated with albumin (ALB), globulin (GLB), A/G, aspartate aminotransferase (AST), ratio of aspartate to alanine aminotransferase (AST/ALT), gamma-glutamyl transferase (GGT), alkaline phosphatase (ALP), alpha-L-fucosidase (AFU), alpha-fetoprotein (AFP) and tumor grades; meanwhile, the pathological grades of tumor was correlated to prealbumin(PALB), GGT and tumor size(all P<0.05). Conclusion: The progress of HCC is correlated with several clinical laboratory biochemistry indices and virus indices. The combined application of these indices is worth studying for auxiliary diagnosis of HCC. |
Key words: N-glycome carcinoma,hepatocellular electrophoresis,capillary |