| 摘要: |
| 目的:观察胰腺导管内乳头状黏液性肿瘤组织黏蛋白MUC1、MUC2 的表达，探讨其可能的临床意义。方法:免疫组织化学EnVision两步法检测MUC1、MUC2蛋白在18例胰腺导管内乳头状黏液性肿瘤(IPMN)和9例胰腺导管腺癌组织中的表达。结果:18例IPMN中有4例表达MUC1，占总数的22%，其中包括1例侵犯周围组织的IPMC；9例胰腺导管腺癌全部表达MUC1，占总数的100%，两者间有统计学差异(P<0.01)。18例IPMN中有17例表达MUC2蛋白，占总数的94.4%；9例胰腺导管腺癌中有1例表达MUC2蛋白，占总数的11.1%，两者间有统计学差异(P<0.01)。不同类型IPMN(IPMA、IPMB、IPMC)中MUC2蛋白表达率有统计学差异(P＜0.05)。结论:IPMN肿瘤组织MUC2蛋白高表达，且表达强度与病理分型相关；MUC1蛋白值得进一步研究作为判断IPMN良恶性的参考指标。 |
| 关键词: 胰腺导管内乳头状黏液性肿瘤 MUC1黏液素 MUC2黏液素 免疫组织化学 |
| DOI：10.3724/SP.J.1008.2008.00266 |
| 投稿时间：2007-10-08修订日期：2008-01-23 |
| 基金项目: |
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| Expression of protein MUC1 and MUC2 in intraductal papillary mucinous neoplasms and its significance |
| HAO Jun1,HU Xian-gui1*,ZHANG Yi-jie1,JIN Gang1,SHAO Cheng-hao1,ZHENG Jian-ming2 |
| (1.Department of General Surgery,Changhai Hospital,Second Military Medical University,Shanghai 200433,China;2.Department of Pathology,Changhai Hospital,Second Military Medical University,Shanghai 200433) |
| Abstract: |
| Objective：To investigate the expression of protein MUC1 and MUC2 in intraductal papillary mucinous neoplasms (IPMNs) and its significance.Methods: Immunohistochemical method (EnVision) was used to analyze the expression of protein MUC1 and MUC2 in 18 IPMNs and 9 pancreatic ductal adenocarcinomas.Results: Expression of protein MUC1 was detected in 4 of the 18 (22%) IPMNs (including 1 with pancreatic intraductal papillary-mucinous carcinoma) and all the 9 (100%) the pancreatic ductal adenocarcinomas,with the latter significantly higher than the former(P<0.01).Expression of protein MUC2 was detected in 17 of the 18 (94.4%) IPMNs and in 1 of the 9 (11.1%) pancreatic ductal adenocarcinomas,with the former significantly higher than the latter(P<0.01).The expression levels of MUC2 were significantly different in IPMNs of different types (IPMA,IPMB,and IPMC,P＜0.05).Conclusion: IPMNs have high expression of MUC2 and the expression is associated with the pathological types of IPMN.MUC1 expression may serve as a marker of malignant IPMNs and is worth further studying. |
| Key words: intraductal papillary mucinous neoplasms MUC1 mucin MUC2 mucin immunohistochemistry |
