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钙结合蛋白S100A1与心力衰竭
许如意1,高连如2*,杨晔2
0
(1.第二军医大学研究生院,上海 200433;2.海军总医院心内科,北京 100037)
摘要:
钙结合蛋白S100A1被认为是一种钙依赖性心脏收缩因子。心力衰竭时S100A1蛋白表达减低,增加S100A1蛋白表达可通过调节心肌钙转运、抑制心室重构、减少心肌细胞凋亡和恢复心肌能量供应等机制增加心脏收缩功能,因此恢复衰竭心肌内S100A1蛋白水平是治疗心力衰竭的有效措施。
关键词:  S100A1蛋白  心肌收缩  心力衰竭  
DOI:10.3724/SP.J.1008.2008.00331
投稿时间:2007-11-01修订日期:2007-12-03
基金项目:
S100A1 protein and heart failure
XU Ru-yi1,GAO Lian-ru2*,YANG Ye
()
Abstract:
S100A,a Ca2+-depending inotropic factor in the heart,is found decreased during hear failure.Increase of S100A1 protein expression can improve cardiac function by regulating Ca2+ transportation,inhibiting left ventricular remodeling,decreasing apoptosis,and restoring energy supply of failing heart.Therefore,recovery of S100A1 protein expression in the failing heart is an effective strategy for treatment of heart failure.
Key words:  S100A1 protein  myocardial contraction  heart failure  calcium