| 摘要: |
| 目的：探讨长期聚丙烯酰胺水凝胶（PAAHG）注射隆乳患者术后乳腺组织免疫应答及细胞增殖的变化。方法：应用免疫组化法检测10例正常乳腺组织,12例无硬结及20例有硬结的注射式隆乳术后患者乳腺组织中CD68、CD25和PCNA的表达情况，结合常规H-E染色切片进行分析。结果：应用亲水性PAAHG注射隆乳术后3~8年，凝胶周围乳腺组织有不同程度的纤维组织增生，并出现炎性细胞及异物巨细胞浸润。CD68、PCNA和CD25阳性细胞极少见于正常乳腺组织中，应用亲水性PAAHG注射隆乳术后，凝胶周围乳腺组织中CD68、PCNA阳性细胞的数目增多，其中有乳房硬结的乳腺组织中CD68、PCNA阳性细胞增多更加明显，3组比较差异具有明显统计学意义（P<0.01）；而CD25阳性细胞数3组比较无统计学差异。结论：亲水性PAAHG长期植入人体后局部可引起一定程度的免疫应答反应及促进细胞增殖。 |
| 关键词: 聚丙烯酰胺水凝胶 乳腺 CD68 CD25 PCNA 细胞增殖 |
| DOI：10.3724/SP.J.1008.2008.00509 |
| 投稿时间：2007-11-28修订日期：2008-04-21 |
| 基金项目: |
|
| Change of immunological response and cell proliferation in breast augmented by polyacrylamide hydrogel injection |
| MA Rui,CHEN Zhen-yu*,LI Hui-chao,LI Hui-chao,ZHANG Zhen-hua |
| (Department of Plastic and Cosmetic Surgery,The Affiliated Hospital of Medical College,Qingdao University,Qingdao 266003,China) |
| Abstract: |
| Objective：To study the change of immunological response and cell proliferation in breast tissues augmented by polyacrylamide hydrogel injection(PHI).Methods:The expression of CD68,CD25 and PCNA in 20 breast tissues with indurations,12 without indurations after breast augmentation by PHI,and 10 normal breast tissues was examined by immunohistochemistry P-V6000; analysis was also done by H-E staining.Results:Hyperplasia of fibrous tissue and infiltration of inflammatory cells and macrophages were found in the breast and adjacent tissues 3-8 years after PHI.Positive cells of CD68 ,CD25 and PCNA hardly existed in the normal tissues,but the breast tissues around the polyacrylamide hydrogel had many positive cells of CD68 and PCNA,especially in cases with indurations;there were significant differences between the 3 groups(P<0.01); and the numbers of cells positive of CD25 were similar between the 3 groups.Conclusion:Long-term implantation of polyacrylamide hydrogel can cause immunological reaction and cell proliferation in the local adjacent tissues. |
| Key words: polyacrylamide hydrogel mammary glands CD68 PCNA CD25 cell proliferation |
