| 摘要: |
| Caplp是由白念珠菌CAP1基因编码的碱性亮氨酸拉链转录因子，既和耐药性有关，又在白念珠菌的氧化应激反应中发挥着举足轻重的作用。Cap1p在AP-1家族转录因子中属于和Yap1p、Yap2p及Pap1p同样的亚家族，其调控靶基因转录的机制是核定位机制。近年来，Cap1p调控的可能靶基因逐一被发现，其与Yap1p之间的异同也逐步被揭示，但是Cap1p和白念珠菌耐药性之间的关系至今尚未阐明。当前抗病原真菌研究领域的两大热点问题正是白念珠菌的氧化应激机制和耐药性产生，因此Cap1p的重要性显得尤为突出。本课题组长期从事白念珠菌转录因子Cap1p的研究工作，本文对Cap1p的研究进展作一介绍。 |
| 关键词: 白念珠菌 Caplp 转录因子 氧化应激 抗药性,真菌 |
| DOI：10.3724/SP.J.1008.2007.00197 |
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| 基金项目:国家自然科学基金（30500628）;上海市青年科技启明星项目（05QMX1470）. |
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| Candida albicans transcription factor Caplp： an update |
| WANG Yan, CAO Yong-bing, GAO Ping-hui, JIANG Yuan-ying |
| (Department of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai 200433, China) |
| Abstract: |
| Caplp, encoded by CAP1, is a basic region-leucine zipper （bZip） transcription factor in Candida albicans. It has been proven to play important roles in both drug resistance and oxidative stress. Within the AP-1 family, Caplp belongs to the same subgroup which also includes Yaplp, Yap2p, and Paplp. The function of Caplp is regulated by a nuclear localization mechanism. In recent years, some target genes of Caplp have been discovered and the differences as well as similarities between Caplp and Yaplp have been revealed. However, the role of Caplp in the drug resistance of Candida albicans still needs to be further investigated. Currently drug resistance and oxidative stress are the 2 focuses in the research of fungal pathogens, making Caplp very important in the future study. The authors have been involved in Caplp research for a long time and this review introduces the current progress in the area |
| Key words: Candida albicans Caplp transcription factors oxidative stress drug resistance fungal |
