| 摘要: |
| 睡眠剥夺作为一种应激源，类似于饥饿、缺氧等，可造成机体正常生理功能紊乱，引起免疫功能下降、学习记忆能力下降及情绪障碍等。氧化应激普遍存在于细胞内，与衰老、阿尔茨海默病、帕金森病等多种神经系统变性疾病相关。目前有研究表明睡眠剥夺可通过多种途径诱发机体的氧化应激，具体包括睡眠剥夺后导致能量消耗代谢及自由基的增多、机体抗氧化能力降低以及通过内质网应激间接引起氧化应激三条途径，本文就此作一综述 |
| 关键词: 睡眠剥夺 氧化应激 |
| DOI：10.3724/SP.J.1008.2007.00201 |
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| 基金项目:上海市科技发展基金（024119029）;第二军医大学长征医院“十一五”“三重三优”学科人才建设计划基金. |
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| Oxidative stress induced by sleep deprivation： an update |
| JIANG Bo,ZHAO Zhong-xin |
| (Department of Neurology,Changzheng Hospital, Second Military Medical University,Shanghai 200003, China) |
| Abstract: |
| Sleep deprivation, as a stress just like starvation and anoxia, can induce the physiological function changes, such as emotion disorders, cognition disorders, and immune disorders. Oxidative stress is common in cells and is closely related to aging, Alzheimer disease, Pakinson diseases, etc. Previous studies showed that sleep deprivation could induce oxidative stress via different pathways, namely, the increase of the metabolic rate and free radicals, the depress of antioxidant ability, and the indirect effects of endoplasmic reticulum stress. In this review we summarize the recent progress on the above fields |
| Key words: sleep deprivation oxidative stress |
