摘要: |
目的:研究复合抗肿瘤药物后对磷酸钙骨水泥(calcium phosphate cement,CPC)理化性质的影响。方法:将甲氨蝶呤(MTX)、表柔比星(EPI)、羟基喜树碱(OH-CPT)、三氧化二砷(As2O3)每种药物分别以2%、5%、8%的比例与CPC复合,检测其固化时间、抗压强度及微结构改变。结果:EPI对CPC复合量为2%时显著延长固化时间(P〈0.05),OH-CPT复合量为5%以及MTX、EPI复合量为8%时CPC最大抗压强度显著下降(P〈0.05)。电镜扫描示药物复合后CPC晶体结构无明显改变。结论:CPC与抗肿瘤药物复合时会导致其理化性质的改变,在临床应用中应做好相关药物复合后的基础研究。[ |
关键词: 骨粘合剂 磷酸钙类 抗肿瘤药 理化性质 |
DOI:10.3724/SP.J.1008.2007.00250 |
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基金项目:国家自然科学基金(30400452). |
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Physicochemical properties of calcium phosphate cement incorporated with anti-tumor drugs |
CHEN Hua-jiang, JIA Lian-shun, XIAO Jian-ru, YANG Xing-hai |
(Department of Orthopeadics, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China) |
Abstract: |
Objective:To study the influence of anti-tumor drug incorporation on the physicochemical properties of calcium phosphate cement(CPC). Methods: Methotrexate (MTX), epirubicin (EPI), hydroxy camptothecin (OH-CPT), and arsenic trioxide (As2O3) were incorporated, each in a proportion of 2%, 5 %, and 8%, into the powder-phase CPC. Untreated CPC was taken as control. The setting time, compression strength, and the microstructure of the resultant products were evaluated and tested. Results: Compared with control group, the setting time was significantly prolonged when 2 % EPI was incorporated into CPC (P〈0.05), and the maximum compression strength was significantly decreased when 5% OH-CPT and 8% MTX, EPI were incorporated into CPC (P〈0.05). Electron microscope showed no significant change in the crystal structure after incorporation of the drugs. Conclusion: CPC is an ideal anti-tumor drug delivery material. The changes of physicochemical properties of CPC must be considered when anti-tumor drugs are incorporated into CPC for clinical application.[ |
Key words: bone cements calcium phosphates antineoplastic agents physicochemical properties |