| 摘要: |
| 成体干细胞在组织修复和再生中具有强大的优势并已成为一种新型的细胞治疗肢体缺血性疾病的细胞来源。本文阐述了关于脂肪组织来源的基质细胞（adipose tissue-derived stromal cells,ADSCs）在组织重建细胞治疗上的巨大潜能。ADSC最大优点在于能方便取得而且容易在体外培养。体外培养的ADSCs能够在特定条件下诱导成为成熟脂肪细胞、骨细胞、神经细胞和内皮细胞。ADSCs还能分泌一定数量的与细胞成熟有关的细胞因子。另外,近年有报道ADSC具有向心肌细胞分化的能力。这些脂肪组织来源的基质细胞有望在不久的将来取代骨髓细胞成为再生细胞治疗的重要材料。[ |
| 关键词: 干细胞 脂肪组织 间质干细胞移植 细胞因子类 |
| DOI：10.3724/SP.J.1008.2007.00322 |
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| 基金项目:全军“十一五”科技攻关项目（06G62）. |
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| Adipose derived stem cells： a novel option for regenerative cell therapy |
| ZHANG Xun-yi ,LIU Hou-qi |
| (1. Research Institute of Developmental Biology, Second Military Medical University, Shanghai 200433, China; 2. Department of Obstetrics and Gynecology, Changhai Hospital, Second Military Medical University, Shanghai 200433) |
| Abstract: |
| Adult stem cells have great advantage in tissue reconstruction and regeneration. Transplantation of autologous stem cells into ischemic tissue is a novel therapeutic option for ischemic disorders. This review summarizes the potential role of adipose tissue-derived stromal cells （ADSC） on regenerative cell therapy for ischemic diseases. ADSC can be readily harvested and cultured, under specific condition,they can be induced to differentiate into adipocytes, bone, neurons,and endothelial cells. Moreover,ADSC can secrete a number of angiogenesis-related cytokines which might be suitable for regenerative cell therapy. It has also been reported that ADSC could differentiate into myocardlocytes. ADSC might be an important material for regenerative cell therapy in the near future,replaclng bone marrow cells.[ |
| Key words: stem cells, adipose tissue mesenchymal stern cell transplantation cytokines |
