| 摘要: |
| 目的：研究CC趋化因子受体5（CCR5）在滤泡状甲状腺癌中的表达,并检测血清中CCR5配体的含量,为进一步探讨CCR5在滤泡状甲状腺癌演进和转移中的作用奠定基础.方法：采用免疫组化方法检测15例滤泡状甲状腺癌患者以及17例甲状腺腺瘤患者,12例癌旁甲状腺组织中CCR5的表达情况, 同时应用酶联免疫吸附试验法（ELISA）检测血清中CCL3、CCL4、CCL5的浓度.结果：滤泡状甲状腺癌组织中,CCR5表达阳性率（11/15）明显高于甲状腺腺瘤和正常甲状腺组织（P＜0.01）.滤泡状甲状腺癌患者血清中CCL3、CCL5的浓度显著高于对照组（P＜0.05）.结论：滤泡状甲状腺癌组织中存在着CCR5高表达,且外周血CCL3,CCL5浓度明显升高,提示CCR5可能在滤泡状甲状腺癌发病进程中发挥着重要的作用. |
| 关键词: CC趋化因子受体5 甲状腺肿瘤 腺癌,滤泡性 CCL3 CCL5 |
| DOI：10.3724/SP.J.1008.2007.00701 |
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| 基金项目:国家自然科学基金（30572200）. |
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| Expression of chemokine receptor CCR5 in human follicular thyroid carcinoma |
| GONG Xue-lian, GUO Bao-yu |
| (Department of Biochemical Pharmacy, School of Pharmacy, Second Military Medical University, Shanghai 200433, China) |
| Abstract: |
| Objective： To study the expression of chemokine receptor CCR5 in follicular thyroid carcinoma and the serum level of CCR5 ligand, so as to assess the role of CCR.5 in progression and metastasis of follicular thyroid carcinoma. Methods： Fifteen samples of follicular thyroid carcinoma, 17 samples of follicular thyroid adenoma and 12 adjacent normal samples were analyzed immunohistochemically for CCR5 expression. The sera concentrations of CCL3, CCL4 and CCL5 were measured by ELISA in all patients. Results： CCR5 was positive in follicular thyroid carcinoma samples, with the positive rate being 73. 33%, and was not detected in the follicular thyroid adenoma and the normal samples（P〈0.01）. The concentrations of CCL3 and CCL5 in the sera of follicular thyroid carcinoma patients were significantly higher than those of the other 2 groups （P〈0.05）. Conclusion： CCR5 is highly expressed in follicular thyroid carcinoma tissues and the concentrations of CCL3 and CCL5 are obviously increased in the sera of patients, indicating that CCR5 may play an important role in the pathogenesis of follicular thyroid carcinoma |
| Key words: CC chemokine receptor 5 thyroid neoplasms adenocarcinoma,follicular CCL3 CCL5 |
