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眼用氟尿嘧啶的制备及体外评价
黄潇,魏锐利*,魏锐利
0
(第二军医大学长征医院眼科,上海 200003;上海长征医院)
摘要:
目的:应用滴入分散法制备眼用氟尿嘧啶-壳聚糖纳米粒(5-Fu-CS-NP),并对其体外释放进行考察。方法:将壳聚糖、聚丙烯酸与氟尿嘧啶通过滴入分散法形成聚电解质络合物制备5-Fu-CS-NP。考察纳米粒粒径、包封率、载药量以及体外释药特性。 结果和结论:5-Fu-CS-NP平均粒径为(144.6±3.1) nm,包封率为84.5%,载药量为3.91%。5-Fu-CS-NP有较好的缓释作用,能在3~7 d内持续释放药物。在pH值7.2~7.4的生理范围内,释放速率变化不大。
关键词:  氟尿嘧啶  壳聚糖  聚丙烯酸  纳米技术  后囊膜混浊
DOI:10.3724/SP.J.1008.2008.00
投稿时间:2008-02-01修订日期:2008-05-19
基金项目:上海市科委纳米专项基金(0452nm015);全军“十一五”医药卫生科研基金(06MA177).
Preparation and in vitro evaluation of fluorouracil nanoparticles for ophthalmologic usage
HUANG Xiao,WEI Rui-li*,weiruili
(Department of Ophthalmology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China)
Abstract:
Objective:To prepare fluorouracil-loaded chitosan nanoparticle (5-Fu-CS-NP) for ophthalmologic usage and evaluate its releasing characteristics in vitro. Methods: 5-Fu-CS-NP was prepared with 5-Fu, polyacrylic acid and chitosan using dispersion method. The mean size, entrapment efficiency (EE%), drug loading (DL%) and the in vitro releasing characteristics of 5-Fu-CS-NP were investigated.Results and conclusion: The mean size of 5-Fu-CS-NP was (144.6±3.1) nm, the EE% was 84.5% and the DL% was 3.91%. 5-Fu-CS-NP had a satisfactory sustained-releasing effect and the releasing could last for 3-7 days, and the release behavior was not greatly changed within a pH value of 7.2-7.4.
Key words:  fluorouracil  chitosan  polyacrylic acid  nanotechnology  posterior capsule opacification