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一种三唑醇类化合物的体内外抗真菌活性研究
欧阳小方,曹永兵,孙青,王彦,姜远英*
0
(第二军医大学药学院药理学教研室,上海 200433)
摘要:
目的:观察三唑醇类化合物SL-130的体内外抗真菌活性。 方法:采用美国临床实验室标准化委员会(NCCLS)1997年公布的M27-A方案,实验用菌株包括白念珠菌及非念珠菌致病真菌,用最低抑菌浓度MIC80表示抗真菌活性。此外利用纸片扩散法、时间-杀菌曲线及小鼠的存活率等方法考察SL-130的抗真菌活性。结果:SL-130具有一定的抗真菌活性,体外明显强于氟康唑,体内与氟康唑基本相当。结论:此三唑醇类化合物结构新颖,体内外的抗真菌活性明显,值得进一步研究。
关键词:  三唑类;抗真菌药  微生物敏感性试验  SL-130
DOI:10.3724/SP.J.1008.2008.00813
投稿时间:2008-03-05修订日期:2008-04-29
基金项目:国家重点基础研究发展计划 (“973”计划,2005CB523105),国家自然科学基金(30300437).
In vitro and in vivo antifungal activity of a triadimenol compound
OUYANG Xiao-fang,CAO Yong-bing,SUN Qing-yan,WANG Yan,JIANG Yuan-ying*
(Department of Pharmacology,School of Pharmacy,Second Military Medical University,Shanghai 200433,China)
Abstract:
Objective:To observe the in vitro and in vivo antifungal activity of a triadimenol compound SL-130.Methods: The M27-A project recommended by the National Committee for Clinical Laboratory Standard (NCCLS) in 1997 was used in the present study.The minimum inhibitory concentrations (MIC80) of SL-130 were determined for candidal and non-candidal strains with different susceptibilities to fluconazole.Agar disk diffusion test,time-kill curves test and mouse survival rate were employed to examine the antifungal activity of SL-130.Results: The results indicated that SL-130 had stronger in vitro antifungal activity than fluconazole,and similar in vivo activity to fluconazole.Conclusion:The structure of SL-130 is quite unique and it has in vitro and in vivo antifungal activity; further study is warranted on the compound.
Key words:  triazoles  antifungal agents  microbial sensitivity tests  SL-130